Asbestos conceives Fe(II)-dependent mutagenic stromal milieu through ceaseless macrophage ferroptosis and β-catenin induction in mesothelium
Asbestos is still a social burden worldwide as a carcinogen causing malignant mesothelioma. Whereas recent studies suggest that local iron reduction is a preventive strategy against carcinogenesis, little is known regarding the cellular and molecular mechanisms surrounding excess iron. Here by diffe...
Main Authors: | Fumiya Ito, Izumi Yanatori, Yuki Maeda, Kenta Nimura, Satoki Ito, Tasuku Hirayama, Hideko Nagasawa, Norihiko Kohyama, Yasumasa Okazaki, Shinya Akatsuka, Shinya Toyokuni |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2020-09-01
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Series: | Redox Biology |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2213231720308211 |
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