INFLUENCE OF PHOTOACTIVATED ROSE BENGAL ON MICROCIRCULATION

INFLUENCE OF PHOTOACTIVATED ROSE BENGAL ON MICROCIRCULATION

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The study of mean blood velocity changes in rat mesenteric venules (15–30 µm) due to photoactivation (λ = 532 nm, 0,175 W/cm2, 300 s) of i.v. injected Rose Bengal (17 mg/kg) is represented in the article. Using in vivo biomicroscopy the progressive decrease of mean blood velocity both during the las...

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Main Authors: T. G. Gryshachova, I. A. Mikhailova, A. V. Struy, S. G. Chephu, N. N. Petrishchev
Format: Article
Language:Russian
Published: Non-profit partnership for development of domestic photodynamic therapy and photodiagnosis "Russian Photodynamic Association" 2017-12-01
Series:Biomedical Photonics
Subjects:
microcirculation
photosensitizer
rose bengal
mean blood velocity
Online Access:https://www.pdt-journal.com/jour/article/view/181
id doaj-80b75d406c094c819c997d3a07b67c83
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spelling doaj-80b75d406c094c819c997d3a07b67c832021-07-29T08:06:58ZrusNon-profit partnership for development of domestic photodynamic therapy and photodiagnosis "Russian Photodynamic Association"Biomedical Photonics2413-94322017-12-0163111510.24931/2413-9432-2017-6-3-11-15117INFLUENCE OF PHOTOACTIVATED ROSE BENGAL ON MICROCIRCULATIONT. G. Gryshachova0I. A. Mikhailova1A. V. Struy2S. G. Chephu3N. N. Petrishchev4I.P. Pavlov State Medical University; Medical Research Centre.I.P. Pavlov State Medical University.I.P. Pavlov State Medical University.I.P. Pavlov State Medical University; Medical Research Centre.I.P. Pavlov State Medical University; Medical Research Centre.The study of mean blood velocity changes in rat mesenteric venules (15–30 µm) due to photoactivation (λ = 532 nm, 0,175 W/cm2, 300 s) of i.v. injected Rose Bengal (17 mg/kg) is represented in the article. Using in vivo biomicroscopy the progressive decrease of mean blood velocity both during the laser irradiation and after it was registered. The calculation of thermal effects in the irradiated part of microvessel due to laser absorption by hemoglobin and Rose Bengal showed the rise of temperature was not exceed 0.2оC as compared to initial level. Thus, thermal effect has nearly no significant influence on microvascular disturbances caused by Rose Bengal photoactivation.https://www.pdt-journal.com/jour/article/view/181microcirculationphotosensitizerrose bengalmean blood velocity
collection DOAJ
language Russian
format Article
sources DOAJ
author T. G. Gryshachova
I. A. Mikhailova
A. V. Struy
S. G. Chephu
N. N. Petrishchev
spellingShingle T. G. Gryshachova
I. A. Mikhailova
A. V. Struy
S. G. Chephu
N. N. Petrishchev
INFLUENCE OF PHOTOACTIVATED ROSE BENGAL ON MICROCIRCULATION
Biomedical Photonics
microcirculation
photosensitizer
rose bengal
mean blood velocity
author_facet T. G. Gryshachova
I. A. Mikhailova
A. V. Struy
S. G. Chephu
N. N. Petrishchev
author_sort T. G. Gryshachova
title INFLUENCE OF PHOTOACTIVATED ROSE BENGAL ON MICROCIRCULATION
title_short INFLUENCE OF PHOTOACTIVATED ROSE BENGAL ON MICROCIRCULATION
title_full INFLUENCE OF PHOTOACTIVATED ROSE BENGAL ON MICROCIRCULATION
title_fullStr INFLUENCE OF PHOTOACTIVATED ROSE BENGAL ON MICROCIRCULATION
title_full_unstemmed INFLUENCE OF PHOTOACTIVATED ROSE BENGAL ON MICROCIRCULATION
title_sort influence of photoactivated rose bengal on microcirculation
publisher Non-profit partnership for development of domestic photodynamic therapy and photodiagnosis "Russian Photodynamic Association"
series Biomedical Photonics
issn 2413-9432
publishDate 2017-12-01
description The study of mean blood velocity changes in rat mesenteric venules (15–30 µm) due to photoactivation (λ = 532 nm, 0,175 W/cm2, 300 s) of i.v. injected Rose Bengal (17 mg/kg) is represented in the article. Using in vivo biomicroscopy the progressive decrease of mean blood velocity both during the laser irradiation and after it was registered. The calculation of thermal effects in the irradiated part of microvessel due to laser absorption by hemoglobin and Rose Bengal showed the rise of temperature was not exceed 0.2оC as compared to initial level. Thus, thermal effect has nearly no significant influence on microvascular disturbances caused by Rose Bengal photoactivation.
topic microcirculation
photosensitizer
rose bengal
mean blood velocity
url https://www.pdt-journal.com/jour/article/view/181
work_keys_str_mv AT tggryshachova influenceofphotoactivatedrosebengalonmicrocirculation
AT iamikhailova influenceofphotoactivatedrosebengalonmicrocirculation
AT avstruy influenceofphotoactivatedrosebengalonmicrocirculation
AT sgchephu influenceofphotoactivatedrosebengalonmicrocirculation
AT nnpetrishchev influenceofphotoactivatedrosebengalonmicrocirculation
_version_ 1721257900162154496

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