Plasma L-cystine/L-glutamate imbalance increases tumor necrosis factor-alpha from CD14+ circulating monocytes in patients with advanced cirrhosis.

Plasma L-cystine/L-glutamate imbalance increases tumor necrosis factor-alpha from CD14+ circulating monocytes in patients with advanced cirrhosis.

BACKGROUND AND AIMS: The innate immune cells can not normally respond to the pathogen in patients with decompensated cirrhosis. Previous studies reported that antigen-presenting cells take up L-Cystine (L-Cys) and secrete substantial amounts of L-Glutamate (L-Glu) via the transport system Xc- (4F2hc...

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Bibliographic Details
Main Authors: Eiji Kakazu, Yoshiyuki Ueno, Yasuteru Kondo, Jun Inoue, Masashi Ninomiya, Osamu Kimura, Yuta Wakui, Koji Fukushima, Keiichi Tamai, Tooru Shimosegawa
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3157377?pdf=render

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http://europepmc.org/articles/PMC3157377?pdf=render

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