Magnetic Iron Oxide Nanoparticles: Synthesis, Characterization and Functionalization for Biomedical Applications in the Central Nervous System

Magnetic Iron Oxide Nanoparticles: Synthesis, Characterization and Functionalization for Biomedical Applications in the Central Nervous System

Magnetic Nanoparticles (MNPs) are of great interest in biomedicine, due to their wide range of applications. During recent years, one of the most challenging goals is the development of new strategies to finely tune the unique properties of MNPs, in order to improve their effectiveness in the biomed...

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Main Authors: Shoeb Anwar Mohammed Khawja Ansari, Eleonora Ficiarà, Federico Alessandro Ruffinatti, Ilaria Stura, Monica Argenziano, Ornella Abollino, Roberta Cavalli, Caterina Guiot, Federico D’Agata
Format: Article
Language:English
Published: MDPI AG 2019-02-01
Series:Materials
Subjects:
iron oxide nanoparticles
magnetic nanoparticles
synthesis
biomedical applications
central nervous system
Online Access:https://www.mdpi.com/1996-1944/12/3/465
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spelling doaj-80abce0009484a1b82bd42143c98d3942020-11-24T21:42:21ZengMDPI AGMaterials1996-19442019-02-0112346510.3390/ma12030465ma12030465Magnetic Iron Oxide Nanoparticles: Synthesis, Characterization and Functionalization for Biomedical Applications in the Central Nervous SystemShoeb Anwar Mohammed Khawja Ansari0Eleonora Ficiarà1Federico Alessandro Ruffinatti2Ilaria Stura3Monica Argenziano4Ornella Abollino5Roberta Cavalli6Caterina Guiot7Federico D’Agata8Department of Neuroscience, University of Turin, 10124 Turin, ItalyDepartment of Neuroscience, University of Turin, 10124 Turin, ItalyDepartment of Drug Sciences, University of Eastern Piedmont Amedeo Avogadro, 28100 Novara, ItalyDepartment of Public Health and Pediatrics, University of Turin, 10124 Turin, ItalyDepartment of Drug Science and Technology, University of Turin, 10124 Turin, ItalyDepartment of Chemistry, University of Turin, 10124 Turin, ItalyDepartment of Drug Science and Technology, University of Turin, 10124 Turin, ItalyDepartment of Neuroscience, University of Turin, 10124 Turin, ItalyDepartment of Neuroscience, University of Turin, 10124 Turin, ItalyMagnetic Nanoparticles (MNPs) are of great interest in biomedicine, due to their wide range of applications. During recent years, one of the most challenging goals is the development of new strategies to finely tune the unique properties of MNPs, in order to improve their effectiveness in the biomedical field. This review provides an up-to-date overview of the methods of synthesis and functionalization of MNPs focusing on Iron Oxide Nanoparticles (IONPs). Firstly, synthesis strategies for fabricating IONPs of different composition, sizes, shapes, and structures are outlined. We describe the close link between physicochemical properties and magnetic characterization, essential to developing innovative and powerful magnetic-driven nanocarriers. In conclusion, we provide a complete background of IONPs functionalization, safety, and applications for the treatment of Central Nervous System disorders.https://www.mdpi.com/1996-1944/12/3/465iron oxide nanoparticlesmagnetic nanoparticlessynthesisbiomedical applicationscentral nervous system
collection DOAJ
language English
format Article
sources DOAJ
author Shoeb Anwar Mohammed Khawja Ansari
Eleonora Ficiarà
Federico Alessandro Ruffinatti
Ilaria Stura
Monica Argenziano
Ornella Abollino
Roberta Cavalli
Caterina Guiot
Federico D’Agata
spellingShingle Shoeb Anwar Mohammed Khawja Ansari
Eleonora Ficiarà
Federico Alessandro Ruffinatti
Ilaria Stura
Monica Argenziano
Ornella Abollino
Roberta Cavalli
Caterina Guiot
Federico D’Agata
Magnetic Iron Oxide Nanoparticles: Synthesis, Characterization and Functionalization for Biomedical Applications in the Central Nervous System
Materials
iron oxide nanoparticles
magnetic nanoparticles
synthesis
biomedical applications
central nervous system
author_facet Shoeb Anwar Mohammed Khawja Ansari
Eleonora Ficiarà
Federico Alessandro Ruffinatti
Ilaria Stura
Monica Argenziano
Ornella Abollino
Roberta Cavalli
Caterina Guiot
Federico D’Agata
author_sort Shoeb Anwar Mohammed Khawja Ansari
title Magnetic Iron Oxide Nanoparticles: Synthesis, Characterization and Functionalization for Biomedical Applications in the Central Nervous System
title_short Magnetic Iron Oxide Nanoparticles: Synthesis, Characterization and Functionalization for Biomedical Applications in the Central Nervous System
title_full Magnetic Iron Oxide Nanoparticles: Synthesis, Characterization and Functionalization for Biomedical Applications in the Central Nervous System
title_fullStr Magnetic Iron Oxide Nanoparticles: Synthesis, Characterization and Functionalization for Biomedical Applications in the Central Nervous System
title_full_unstemmed Magnetic Iron Oxide Nanoparticles: Synthesis, Characterization and Functionalization for Biomedical Applications in the Central Nervous System
title_sort magnetic iron oxide nanoparticles: synthesis, characterization and functionalization for biomedical applications in the central nervous system
publisher MDPI AG
series Materials
issn 1996-1944
publishDate 2019-02-01
description Magnetic Nanoparticles (MNPs) are of great interest in biomedicine, due to their wide range of applications. During recent years, one of the most challenging goals is the development of new strategies to finely tune the unique properties of MNPs, in order to improve their effectiveness in the biomedical field. This review provides an up-to-date overview of the methods of synthesis and functionalization of MNPs focusing on Iron Oxide Nanoparticles (IONPs). Firstly, synthesis strategies for fabricating IONPs of different composition, sizes, shapes, and structures are outlined. We describe the close link between physicochemical properties and magnetic characterization, essential to developing innovative and powerful magnetic-driven nanocarriers. In conclusion, we provide a complete background of IONPs functionalization, safety, and applications for the treatment of Central Nervous System disorders.
topic iron oxide nanoparticles
magnetic nanoparticles
synthesis
biomedical applications
central nervous system
url https://www.mdpi.com/1996-1944/12/3/465
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