High throughput mutagenesis for identification of residues regulating human prostacyclin (hIP) receptor expression and function.

High throughput mutagenesis for identification of residues regulating human prostacyclin (hIP) receptor expression and function.

The human prostacyclin receptor (hIP receptor) is a seven-transmembrane G protein-coupled receptor (GPCR) that plays a critical role in vascular smooth muscle relaxation and platelet aggregation. hIP receptor dysfunction has been implicated in numerous cardiovascular abnormalities, including myocard...

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Bibliographic Details
Main Authors: Anke Bill, Elizabeth M Rosethorne, Toby C Kent, Lindsay Fawcett, Lynn Burchell, Michiel T van Diepen, Anthony Marelli, Sergey Batalov, Loren Miraglia, Anthony P Orth, Nicole A Renaud, Steven J Charlton, Martin Gosling, L Alex Gaither, Paul J Groot-Kormelink
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4041722?pdf=render

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