E2F-1 as an anticancer drug target
Mounting evidence indicates that the E2F transcription factors play an essential role in all aspects of cellular functions. Many human malignancies have been shown to overexpress one or more of the ‘‘activating’’ E2Fs. In some circumstances, down regulation as well as overexpression of E2F-1, leads...
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PAGEPress Publications
2011-12-01
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| Series: | Oncology Reviews |
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| Online Access: | http://www.oncologyreviews.org/index.php/or/article/view/96 |
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doaj-80a474be946c40f6a8dc22e4006b4f172020-11-25T03:29:34ZengPAGEPress PublicationsOncology Reviews1970-55571970-55652011-12-013410.4081/oncol.2009.20790E2F-1 as an anticancer drug targetJoseph R. Bertino0Debabrata Banerjee1Departments of Medicine and Pharmacology, Cancer Institute of New Jersey, Robert Wood Johnson Medical School, University of Medicine and Dentistry, New BrunswickDepartments of Medicine and Pharmacology, Cancer Institute of New Jersey, Robert Wood Johnson Medical School, University of Medicine and Dentistry, New BrunswickMounting evidence indicates that the E2F transcription factors play an essential role in all aspects of cellular functions. Many human malignancies have been shown to overexpress one or more of the ‘‘activating’’ E2Fs. In some circumstances, down regulation as well as overexpression of E2F-1, leads to inhibition of cell growth. The emphasis in this review is placed on new data implicating microRNAs in the regulation of E2F activity and the efforts thus far to target this activity in order to cause tumor regression.http://www.oncologyreviews.org/index.php/or/article/view/96E2F-1 - Retinoblastoma protein - Cancer - MicroRNAs |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Joseph R. Bertino Debabrata Banerjee |
| spellingShingle |
Joseph R. Bertino Debabrata Banerjee E2F-1 as an anticancer drug target Oncology Reviews E2F-1 - Retinoblastoma protein - Cancer - MicroRNAs |
| author_facet |
Joseph R. Bertino Debabrata Banerjee |
| author_sort |
Joseph R. Bertino |
| title |
E2F-1 as an anticancer drug target |
| title_short |
E2F-1 as an anticancer drug target |
| title_full |
E2F-1 as an anticancer drug target |
| title_fullStr |
E2F-1 as an anticancer drug target |
| title_full_unstemmed |
E2F-1 as an anticancer drug target |
| title_sort |
e2f-1 as an anticancer drug target |
| publisher |
PAGEPress Publications |
| series |
Oncology Reviews |
| issn |
1970-5557 1970-5565 |
| publishDate |
2011-12-01 |
| description |
Mounting evidence indicates that the E2F transcription factors play an essential role in all aspects of cellular functions. Many human malignancies have been shown to overexpress one or more of the ‘‘activating’’ E2Fs. In some circumstances, down regulation as well as overexpression of E2F-1, leads to inhibition of cell growth. The emphasis in this review is placed on new data implicating microRNAs in the regulation of E2F activity and the efforts thus far to target this activity in order to cause tumor regression. |
| topic |
E2F-1 - Retinoblastoma protein - Cancer - MicroRNAs |
| url |
http://www.oncologyreviews.org/index.php/or/article/view/96 |
| work_keys_str_mv |
AT josephrbertino e2f1asananticancerdrugtarget AT debabratabanerjee e2f1asananticancerdrugtarget |
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