Placental Glucose Transporters and Response to Bisphenol A in Pregnancies from of Normal and Overweight Mothers

• Main Authors: Leonardo Ermini, Anna Maria Nuzzo, Francesca Ietta, Roberta Romagnoli, Laura Moretti, Bianca Masturzo, Luana Paulesu, Alessandro Rolfo
• Format: Article
• Language: English
• Published: MDPI AG 2021-06-01
• Series: International Journal of Molecular Sciences
• Subjects: BPA; GLUT1; GLUT4; human pregnancy; human placenta
• Online Access: https://www.mdpi.com/1422-0067/22/12/6625
• ISSN: 1661-6596; 1422-0067

Bisphenol A (BPA) is a synthetic phenol extensively used in the manufacture of polycarbonate plastics and epoxy resins and a component of liquid and food storages. Among health disorders potentially attributed to BPA, the effects on metabolism have been especially studied. BPA represents a hazard in prenatal life because of its presence in tissues and fluids during pregnancy. Our recent study in rats fed with BPA showed a placental increase in glucose type 1 transporter (GLUT-1), suggesting a higher uptake of glucose. However, the role of BPA on GLUT transporters in pregnant women with metabolic dysfunction has not yet been investigated. In this study, placental tissue from 26 overweight (OW) women and 32 age-matched normal weight (NW) pregnant women were examined for expression of GLUT1 and GLUT4. Placental explants from OW and NW mothers were exposed to BPA 1 nM and 1 μM and tested for GLUTs expression. The data showed a different response of placental explants to BPA in GLUT1 expression with an increase in NW mothers and a decrease in OW ones. GLUT4 expression was lower in the explants from OW than NW mothers, while no difference was showed between OW and NW in placental biopsies for any of the transporters.