Identification of a Novel Polyamine Scaffold With Potent Efflux Pump Inhibition Activity Toward Multi-Drug Resistant Bacterial Pathogens

Identification of a Novel Polyamine Scaffold With Potent Efflux Pump Inhibition Activity Toward Multi-Drug Resistant Bacterial Pathogens

We have previously reported the use of combinatorial chemistry to identify broad-spectrum antibacterial agents. Herein, we extend our analysis of this technology toward the discovery of anti-resistance molecules, focusing on efflux pump inhibitors. Using high-throughput screening against multi-drug...

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Bibliographic Details
Main Authors: Renee M. Fleeman, Ginamarie Debevec, Kirsten Antonen, Jessie L. Adams, Radleigh G. Santos, Gregory S. Welmaker, Richard A. Houghten, Marc A. Giulianotti, Lindsey N. Shaw
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Microbiology
Subjects:
efflux pumps
efflux pump inhibitors
polyamines
bacterial resistance
potentiation
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2018.01301/full

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