| Summary: | Rehab H Werida,1 Ayman Omran,2 Noha M El-Khodary1 1Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmacy, Damanhour University, Damanhour, Egypt; 2Department of Cardiology, Damanhour National Medical Institute, Damanhour, EgyptCorrespondence: Noha M El-KhodaryDepartment of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmacy, Damanhour University, Damanhour, EgyptTel +201273740276Fax +20 45 3334595Email noha.mahmoud@pharm.dmu.edu.eg; nohamahmoud_55@hotmail.comPurpose: The aim of this study was to assess the relationship of coronary artery disease (CAD) with levels of homocysteine and sortilin in Egyptian patients.Background: CAD is a primary contributor to cardiac disease and a prominent cause of death globally.Patients and Methods: We enrolled 45 patients with CAD evaluated by coronary CT angiography and 42 control subjects without CAD. Plasma-homocysteine and -sortilin levels were measured with a commercial ELISA kit.Results: Elevated levels of homocysteine and sortilin were observed in the CAD patients compared to controls (13.75± 1.40 vs 7.73± 2.06 μmol/L, P=0 and 160.91± 32.17 vs 143.02± 32.30 ng/dL, P=0.02, respectively). Significantly higher total cholesterol, low density–lipoprotein cholesterol and triglycerides (P< 0.05) and lower high density–lipoprotein cholesterol (P< 0.05) were seen among patients with CAD than the control group. Sortilin levels were positively associated with homocysteine levels (r=0.32, P=0.006), total cholesterol (r=0.61, P=0), low density–lipoprotein cholesterol (r=0.37, P=0.001), triglycerides (r=0.91, P=0), troponin I (r=0.82, P=0), Gensini score (r=0.93, P=0) and high-sensitivity CRP (r=0.87, P=0) in all subjects. Homocysteine has a significantly negative association with high density–lipoprotein cholesterol (r=− 0.42, P=0).Conclusion: Elevated homocysteine and sortilin levels are crucial risk factors of CAD in Egyptian patients.Keywords: sortilin, homocysteine, coronary artery disease
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