TERRA-Reinforced Association of LSD1 with MRE11 Promotes Processing of Uncapped Telomeres

Telomeres protect chromosome ends from being recognized as sites of DNA damage. Upon telomere shortening or telomere uncapping induced by loss of telomeric repeat-binding factor 2 (TRF2), telomeres elicit a DNA-damage response leading to cellular senescence. Here, we show that following TRF2 depleti...

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Bibliographic Details
Main Authors: Antonio Porro, Sascha Feuerhahn, Joachim Lingner
Format: Article
Language:English
Published: Elsevier 2014-02-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124714000394

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