Residue Mutations in Murine Herpesvirus 68 Immunomodulatory Protein M3 Reveal Specific Modulation of Chemokine Binding

Residue Mutations in Murine Herpesvirus 68 Immunomodulatory Protein M3 Reveal Specific Modulation of Chemokine Binding

The M3 protein (M3) encoded by murine gammaherpesvirus 68 (MHV-68) is a unique viral immunomodulator with a high-affinity for a broad spectrum of chemokines, key mediators responsible for the migration of immune cells to sites of inflammation. M3 is currently being studied as a very attractive and d...

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Bibliographic Details
Main Authors: Radka Šebová, Vladena Bauerová-Hlinková, Konrad Beck, Ivana Nemčovičová, Jacob Bauer, Marcela Kúdelová
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
MHV-68
M3 protein
site-directed mutagenesis
chemokine binding
CCL5
CXCL8
Online Access:https://www.frontiersin.org/article/10.3389/fcimb.2019.00210/full

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https://www.frontiersin.org/article/10.3389/fcimb.2019.00210/full

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