| Summary: | Objectives: This study aimed to explore the effects of Psidium guajava L. extracts on mice diarrhea model and changes in their intestinal microflora diversity. Methods: Mice diarrhea model was constructed with Folium Sennae. and The therapeutic effects of Psidium guajava L. extracts on diarrhea were evaluated by loose stools rates, diarrhea rates, diarrhea index and motor functions of intestine. Results: Our results showed that all three kinds of extracts from Psidium guajava L. had inhibitory effects on Folium Sennae —induced diarrhea model. The proportion of Bacteroidetes is lower in Group DF (diarrhea model group) compared with Group B (blank group), while abundance of Deferribacteraceae was found in Group DF. The proportion of Deferribacteraceae lowered in Group DTF (diarrhea treatment group) treated with extracts from Psidium guajava L. Conclusions: However, mechanisms underlying the therapeutic effect of Psidium guajava L. and the changes in intestinal microflora still await further exploration. Keywords: Psidium guajava L., Diarrhea, Intestinal microflora, ERIC-PCR, 16S-rDNA, Bacteroidetes, Deferribacteraceae
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