A rare breed: Wild-type braf and ighv expression in a 29 year old lady with classical hairy cell leukemia

A rare breed: Wild-type braf and ighv expression in a 29 year old lady with classical hairy cell leukemia

The V600 BRAF mutation has been described as a key mutation in the pathogenesis of classical hairy cell leukemia (c-HCL) cases without expression of a mutant immunoglobulin heavy chain (IgHV). Here we present a rare case of c-HCL with neither V600 BRAF mutation nor the aforementioned IgHV variant su...

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Main Authors: Aneesha Hossain, Hind Rafei, Amar Jariwala, Khaled El-Shami
Format: Article
Language:English
Published: Elsevier 2017-01-01
Series:Leukemia Research Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2213048916300462
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spelling doaj-8084d8fa086d471981f6fe438e3615722020-11-24T23:42:20ZengElsevierLeukemia Research Reports2213-04892017-01-017C202210.1016/j.lrr.2017.01.001A rare breed: Wild-type braf and ighv expression in a 29 year old lady with classical hairy cell leukemiaAneesha Hossain0Hind Rafei1Amar Jariwala2Khaled El-Shami3Department of Internal Medicine, George Washington U niversity School of Medicine and Health Sciences, Washington, DC, United States of AmericaDepartment of Internal Medicine, George Washington U niversity School of Medicine and Health Sciences, Washington, DC, United States of AmericaDepartment of Pathology, George Washington University Medical Faculty Associates, Washington, DC, United States of AmericaDepartment of Hematology and Oncology, George Washington University Medical Faculty Associates, 2150 Pennsylvania Ave NW, Washington, DC 20037, United States of AmericaThe V600 BRAF mutation has been described as a key mutation in the pathogenesis of classical hairy cell leukemia (c-HCL) cases without expression of a mutant immunoglobulin heavy chain (IgHV). Here we present a rare case of c-HCL with neither V600 BRAF mutation nor the aforementioned IgHV variant successfully treated with cladribine and review the current literature on its use in women of childbearing age/pregnancy.http://www.sciencedirect.com/science/article/pii/S2213048916300462
collection DOAJ
language English
format Article
sources DOAJ
author Aneesha Hossain
Hind Rafei
Amar Jariwala
Khaled El-Shami
spellingShingle Aneesha Hossain
Hind Rafei
Amar Jariwala
Khaled El-Shami
A rare breed: Wild-type braf and ighv expression in a 29 year old lady with classical hairy cell leukemia
Leukemia Research Reports
author_facet Aneesha Hossain
Hind Rafei
Amar Jariwala
Khaled El-Shami
author_sort Aneesha Hossain
title A rare breed: Wild-type braf and ighv expression in a 29 year old lady with classical hairy cell leukemia
title_short A rare breed: Wild-type braf and ighv expression in a 29 year old lady with classical hairy cell leukemia
title_full A rare breed: Wild-type braf and ighv expression in a 29 year old lady with classical hairy cell leukemia
title_fullStr A rare breed: Wild-type braf and ighv expression in a 29 year old lady with classical hairy cell leukemia
title_full_unstemmed A rare breed: Wild-type braf and ighv expression in a 29 year old lady with classical hairy cell leukemia
title_sort rare breed: wild-type braf and ighv expression in a 29 year old lady with classical hairy cell leukemia
publisher Elsevier
series Leukemia Research Reports
issn 2213-0489
publishDate 2017-01-01
description The V600 BRAF mutation has been described as a key mutation in the pathogenesis of classical hairy cell leukemia (c-HCL) cases without expression of a mutant immunoglobulin heavy chain (IgHV). Here we present a rare case of c-HCL with neither V600 BRAF mutation nor the aforementioned IgHV variant successfully treated with cladribine and review the current literature on its use in women of childbearing age/pregnancy.
url http://www.sciencedirect.com/science/article/pii/S2213048916300462
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