Derivatives of acridone acetic acid in pediatric practice

• Main Authors: A. A. Shuldyakov, E. P. Lyapina, V. K. Polyakov, Yu. B. Barylnik, O. B. Lisko, N. I. Mishagin
• Format: Article
• Language: Russian
• Published: Ltd. “The National Academy of Pediatric Science and Innovation” 2019-05-01
• Series: Rossijskij Vestnik Perinatologii i Pediatrii
• Subjects: children; viral infections; interferon; cycloferon
• Online Access: https://www.ped-perinatology.ru/jour/article/view/866

The article justifies the use of interferon inducers in a clinical practice of pediatrician. The authors isolated a group of derivatives of acridone acetic acid, which effectiveness is associated with the features of pharmacokinetics and pharmacological activity. They demonstrated preventive and therapeutic efficacy of cycloferon in the complex treatment of children with influenza and other acute respiratory viral infections, herpes virus, arbovirus, rotavirus infections, viral hepatitis and tick-borne encephalitis due to its immunomodulatory potency. The article analyzed the use of cycloferon in frequently sick children, patients with allergic diseases, chronic tonsillitis, etc.; also it showed a decrease in the frequency of relapses of both infectious and allergic diseases, the possibility of combined use with other etiotropic and symptomatic drugs.