Gene expression profiling following <it>NRF2</it> and <it>KEAP1</it> siRNA knockdown in human lung fibroblasts identifies CCL11/Eotaxin-1 as a novel NRF2 regulated gene

Gene expression profiling following <it>NRF2</it> and <it>KEAP1</it> siRNA knockdown in human lung fibroblasts identifies CCL11/Eotaxin-1 as a novel NRF2 regulated gene

<p>Abstract</p> <p>Background</p> <p>Oxidative Stress contributes to the pathogenesis of many diseases. The NRF2/KEAP1 axis is a key transcriptional regulator of the anti-oxidant response in cells. <it>Nrf2</it> knockout mice have implicated this pathway in...

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Bibliographic Details
Main Authors: Fourtounis Jimmy, Wang I-Ming, Mathieu Marie-Claude, Claveau David, Loo Tenneille, Jackson Aimee L, Peters Mette A, Therien Alex G, Boie Yves, Crackower Michael A
Format: Article
Language:English
Published: BMC 2012-10-01
Series:Respiratory Research
Subjects:
Asthma
NRF2
KEAP1
Oxidative stress
Eotaxin regulation
Microarray profiling
Online Access:http://respiratory-research.com/content/13/1/92

Internet

http://respiratory-research.com/content/13/1/92

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