Post-radiation breast angiosarcoma in a patient with four preceded cancers: Case report and Literature review

• Main Author: Lazaros Papadopoulos, Vassileios Barbounis, Kalliopi Petraki, Georgios Pechlivanidis
• Format: Article
• Language: English
• Published: Bulgarian Association of Young Surgeons 2020-04-01
• Series: International Journal of Surgery and Medicine
• Subjects: post radiation angiosarcoma; breast cancer; multiple cancers in breast cancer; breast angiosarcoma; prochronous cancers; breast multiple cancers; pras
• Online Access: http://www.ejos.org/index.php?fulltxt=63225&fulltxtj=136&fulltxtp=136-1567025715.pdf

Angiosarcoma is a rare vascular lesion and radiation predisposes for its development. Multiple cancers development is even more rare and may be related to genetic predisposition. We present a case of a woman with an angiosarcoma developed on an irradiated breast, treated with mastectomy and chemotherapy, who also had a past medical history of other 4 preceded cancers in a 20-year period. The rarity of our case report is based upon the fact that a patient with a rare diagnosis of post radiation angiosarcoma had a medical history of other 4 preceded cancers in a 20-year period. We also present a literature review on breast angiosarcomas and multiple cancers development. Every lesion, especially angiomatous like lesions on irradiated skin, approximately 6 to 10 years after irradiation should arouse suspicion and be biopsied, especially in patients with medical history of prochronous cancers.