microRNA-27b shuttled by mesenchymal stem cell-derived exosomes prevents sepsis by targeting JMJD3 and downregulating NF-κB signaling pathway

microRNA-27b shuttled by mesenchymal stem cell-derived exosomes prevents sepsis by targeting JMJD3 and downregulating NF-κB signaling pathway

Abstract Background Exosomal microRNAs (miRs) derived from mesenchymal stem cells (MSCs) have been shown to play roles in the pathophysiological processes of sepsis. Moreover, miR-27b is highly enriched in MSC-derived exosomes. Herein, we aimed to investigate the potential role and downstream molecu...

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Bibliographic Details
Main Authors: Jia Sun, Xuan Sun, Junhui Chen, Xin Liao, Yixuan He, Jinsong Wang, Rui Chen, Sean Hu, Chen Qiu
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Stem Cell Research & Therapy
Subjects:
Sepsis
Mesenchymal stem cells
Exosome
MicroRNA-27b
Jumonji D3
Nuclear factor κB/p65
Online Access:https://doi.org/10.1186/s13287-020-02068-w

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