Alterations in Neurogenic Inflammatory Responses in Mice Lacking αCGRP

Alterations in Neurogenic Inflammatory Responses in Mice Lacking αCGRP

a-Calcitonin gene-related peptide (aCGRP) is a pleiotropic peptide neuromodulator that is widely expressed throughout the central and peripheral nervous systems. Although CGRP has been implicated in numerous physiological processes (including peripheral vasodilatation, acetylcholine receptor biosynt...

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Main Authors: Jongho Lee, Ronald B. Emeson
Format: Article
Language:English
Published: Hindawi Limited 2001-01-01
Series:The Scientific World Journal
Online Access:http://dx.doi.org/10.1100/tsw.2001.423
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spelling doaj-806bd96031a44aa0aa386742b198c3222020-11-24T21:47:13ZengHindawi LimitedThe Scientific World Journal1537-744X2001-01-0117710.1100/tsw.2001.423Alterations in Neurogenic Inflammatory Responses in Mice Lacking αCGRPJongho Lee0Ronald B. Emeson1Department of Pharmacology, Vanderbilt University, Nashville, TN 37232-6600, USADepartment of Pharmacology, Vanderbilt University, Nashville, TN 37232-6600, USAa-Calcitonin gene-related peptide (aCGRP) is a pleiotropic peptide neuromodulator that is widely expressed throughout the central and peripheral nervous systems. Although CGRP has been implicated in numerous physiological processes (including peripheral vasodilatation, acetylcholine receptor biosynthesis, nociception, and neurogenic inflammation), the precise physiological roles of CGRP remain to be elucidated. To provide a better understanding of the physiological role(s) mediated by this peptide neurotransmitter, we have generated aCGRP-null mice by targeted modification in embryonic stem cells.http://dx.doi.org/10.1100/tsw.2001.423
collection DOAJ
language English
format Article
sources DOAJ
author Jongho Lee
Ronald B. Emeson
spellingShingle Jongho Lee
Ronald B. Emeson
Alterations in Neurogenic Inflammatory Responses in Mice Lacking αCGRP
The Scientific World Journal
author_facet Jongho Lee
Ronald B. Emeson
author_sort Jongho Lee
title Alterations in Neurogenic Inflammatory Responses in Mice Lacking αCGRP
title_short Alterations in Neurogenic Inflammatory Responses in Mice Lacking αCGRP
title_full Alterations in Neurogenic Inflammatory Responses in Mice Lacking αCGRP
title_fullStr Alterations in Neurogenic Inflammatory Responses in Mice Lacking αCGRP
title_full_unstemmed Alterations in Neurogenic Inflammatory Responses in Mice Lacking αCGRP
title_sort alterations in neurogenic inflammatory responses in mice lacking αcgrp
publisher Hindawi Limited
series The Scientific World Journal
issn 1537-744X
publishDate 2001-01-01
description a-Calcitonin gene-related peptide (aCGRP) is a pleiotropic peptide neuromodulator that is widely expressed throughout the central and peripheral nervous systems. Although CGRP has been implicated in numerous physiological processes (including peripheral vasodilatation, acetylcholine receptor biosynthesis, nociception, and neurogenic inflammation), the precise physiological roles of CGRP remain to be elucidated. To provide a better understanding of the physiological role(s) mediated by this peptide neurotransmitter, we have generated aCGRP-null mice by targeted modification in embryonic stem cells.
url http://dx.doi.org/10.1100/tsw.2001.423
work_keys_str_mv AT jongholee alterationsinneurogenicinflammatoryresponsesinmicelackingacgrp
AT ronaldbemeson alterationsinneurogenicinflammatoryresponsesinmicelackingacgrp
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