AhR Activation Leads to Alterations in the Gut Microbiome with Consequent Effect on Induction of Myeloid Derived Suppressor Cells in a CXCR2-Dependent Manner

AhR Activation Leads to Alterations in the Gut Microbiome with Consequent Effect on Induction of Myeloid Derived Suppressor Cells in a CXCR2-Dependent Manner

Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a potent ligand for AhR and a known carcinogen. While AhR activation by TCDD leads to significant immunosuppression, how this translates into carcinogenic signal is unclear. R...

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Bibliographic Details
Main Authors: Wurood Hantoosh Neamah, Philip Brandon Busbee, Hasan Alghetaa, Osama A. Abdulla, Mitzi Nagarkatti, Prakash Nagarkatti
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:International Journal of Molecular Sciences
Subjects:
2,3,7,8-tetrachlorodibenzo-p-dioxin
aryl hydrocarbon receptor
microbiome
myeloid-derived suppressor cell
CXCR2
Online Access:https://www.mdpi.com/1422-0067/21/24/9613

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https://www.mdpi.com/1422-0067/21/24/9613

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