A novel phase variation mechanism in the meningococcus driven by a ligand-responsive repressor and differential spacing of distal promoter elements.

A novel phase variation mechanism in the meningococcus driven by a ligand-responsive repressor and differential spacing of distal promoter elements.

Phase variable expression, mediated by high frequency reversible changes in the length of simple sequence repeats, facilitates adaptation of bacterial populations to changing environments and is frequently important in bacterial virulence. Here we elucidate a novel phase variable mechanism for NadA,...

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Bibliographic Details
Main Authors: Matteo M E Metruccio, Eva Pigozzi, Davide Roncarati, Francesco Berlanda Scorza, Nathalie Norais, Stuart A Hill, Vincenzo Scarlato, Isabel Delany
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-12-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC2791445?pdf=render

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http://europepmc.org/articles/PMC2791445?pdf=render

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