Efficiency of using the anxiolytic adaptol in the combination therapy of arterial hypertension in women

• Main Author: S N Duma
• Format: Article
• Language: Russian
• Published: "Consilium Medicum" Publishing house 2013-04-01
• Series: Терапевтический архив
• Subjects: combination antihypertensive therapy; adaptol; correction of psychoautonomic disorders
• Online Access: https://ter-arkhiv.ru/0040-3660/article/view/31264
• ISSN: 0040-3660; 2309-5342

AIM: To evaluate the effect of the anxiolytic adaptol on blood pressure (BP) level in its concurrent use with a fixed dose angiotensin-converting enzyme (ACE) inhibitor/diuretic combination on quality of life and on the correction of psychoautonomic disorders/MATERIAL AND METHODS: The trial included women aged 40-60 years with the verified diagnosis of Stage 2B arterial hypertension (AH), risk 2, and a disease history of at least 5 years. A study group received a fixed dose ACE inhibitor/diuretic combination once daily and adaptol 500 mg twice daily for 2 months. A comparison group had only the fixed dose ACE inhibitor/diuretic combination once daily without adaptol/RESULTS: By the end of one-month therapy, a more pronounced statistically significant BP reduction was achieved in the study group receiving the ACE inhibitor/diuretic combination and adaptol than in the comparison group. The quality of life was improved in 6 of the 8 items in the study group and in 3 items in the comparison group. The total scores of psychoautonomic disorders decreased from 48.7 to 25.8 in the study group and from 47.8 to 38 in the comparison one/CONCLUSION: It is expedient to combine antihypertensive therapy and anxiolytics in female hypertensive patients with autonomic dystonic disorders.