A case of pulmonary pleomorphic carcinoma with malignant phenotypes induced by ZEB1-associated epithelial-mesenchymal transition

A case of pulmonary pleomorphic carcinoma with malignant phenotypes induced by ZEB1-associated epithelial-mesenchymal transition

A 60-year-old man was admitted to our hospital with non-small cell lung cancer (NSCLC). Imaging and pathological studies revealed NSCLC, not otherwise specified (NOS), at clinical stage T3N1M0 stage IIIA. We started radiotherapy alone because of obstructive pneumonia and end-stage renal disease, but...

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Main Authors: Mayo Kondo, Hirokazu Ogino, Hirohisa Ogawa, Tania Afroj, Yuko Toyoda, Satoshi Sakaguchi, Miki Tsuboi, Yoshimi Bando, Hisatsugu Goto, Koichi Tsuneyama, Yasuhiko Nishioka
Format: Article
Language:English
Published: Elsevier 2018-01-01
Series:Respiratory Medicine Case Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2213007118300327
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spelling doaj-805048f595304353a82a122880da161d2020-11-25T00:08:13ZengElsevierRespiratory Medicine Case Reports2213-00712018-01-0125119121A case of pulmonary pleomorphic carcinoma with malignant phenotypes induced by ZEB1-associated epithelial-mesenchymal transitionMayo Kondo0Hirokazu Ogino1Hirohisa Ogawa2Tania Afroj3Yuko Toyoda4Satoshi Sakaguchi5Miki Tsuboi6Yoshimi Bando7Hisatsugu Goto8Koichi Tsuneyama9Yasuhiko Nishioka10Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, JapanDepartment of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, JapanDepartment of Pathology and Laboratory Medicine, Graduate School of Biomedical Sciences, Tokushima University, JapanDepartment of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, JapanDepartment of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, JapanDepartment of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, JapanDepartment of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, JapanDivision of Pathology, Tokushima University Hospital, JapanDepartment of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, JapanDepartment of Pathology and Laboratory Medicine, Graduate School of Biomedical Sciences, Tokushima University, JapanDepartment of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, Japan; Corresponding author. Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, 3-18-15, Kuramoto-cho, Tokushima 770-8503, Japan.A 60-year-old man was admitted to our hospital with non-small cell lung cancer (NSCLC). Imaging and pathological studies revealed NSCLC, not otherwise specified (NOS), at clinical stage T3N1M0 stage IIIA. We started radiotherapy alone because of obstructive pneumonia and end-stage renal disease, but the tumors progressed rapidly and resulted in death due to air obstruction by pharyngeal metastasis. The cancer was diagnosed as pleomorphic carcinoma in an autopsy. Viable lung tumor cells, which were resistant to radiotherapy, and the pharyngeal metastasis had mesenchymal phenotypes and expressed ZEB1 but not SNAI1. These observations indicated that ZEB1-associated epithelial-mesenchymal transition has malignant features including resistance to radiotherapy and aggressive metastatic potential. ZEB1-associated EMT may be an important mechanism to understand the pathophysiology of pleomorphic carcinoma. Keywords: Pulmonary pleomorphic carcinoma, Epithelial-mesenchymal transition (EMT), ZEB1http://www.sciencedirect.com/science/article/pii/S2213007118300327
collection DOAJ
language English
format Article
sources DOAJ
author Mayo Kondo
Hirokazu Ogino
Hirohisa Ogawa
Tania Afroj
Yuko Toyoda
Satoshi Sakaguchi
Miki Tsuboi
Yoshimi Bando
Hisatsugu Goto
Koichi Tsuneyama
Yasuhiko Nishioka
spellingShingle Mayo Kondo
Hirokazu Ogino
Hirohisa Ogawa
Tania Afroj
Yuko Toyoda
Satoshi Sakaguchi
Miki Tsuboi
Yoshimi Bando
Hisatsugu Goto
Koichi Tsuneyama
Yasuhiko Nishioka
A case of pulmonary pleomorphic carcinoma with malignant phenotypes induced by ZEB1-associated epithelial-mesenchymal transition
Respiratory Medicine Case Reports
author_facet Mayo Kondo
Hirokazu Ogino
Hirohisa Ogawa
Tania Afroj
Yuko Toyoda
Satoshi Sakaguchi
Miki Tsuboi
Yoshimi Bando
Hisatsugu Goto
Koichi Tsuneyama
Yasuhiko Nishioka
author_sort Mayo Kondo
title A case of pulmonary pleomorphic carcinoma with malignant phenotypes induced by ZEB1-associated epithelial-mesenchymal transition
title_short A case of pulmonary pleomorphic carcinoma with malignant phenotypes induced by ZEB1-associated epithelial-mesenchymal transition
title_full A case of pulmonary pleomorphic carcinoma with malignant phenotypes induced by ZEB1-associated epithelial-mesenchymal transition
title_fullStr A case of pulmonary pleomorphic carcinoma with malignant phenotypes induced by ZEB1-associated epithelial-mesenchymal transition
title_full_unstemmed A case of pulmonary pleomorphic carcinoma with malignant phenotypes induced by ZEB1-associated epithelial-mesenchymal transition
title_sort case of pulmonary pleomorphic carcinoma with malignant phenotypes induced by zeb1-associated epithelial-mesenchymal transition
publisher Elsevier
series Respiratory Medicine Case Reports
issn 2213-0071
publishDate 2018-01-01
description A 60-year-old man was admitted to our hospital with non-small cell lung cancer (NSCLC). Imaging and pathological studies revealed NSCLC, not otherwise specified (NOS), at clinical stage T3N1M0 stage IIIA. We started radiotherapy alone because of obstructive pneumonia and end-stage renal disease, but the tumors progressed rapidly and resulted in death due to air obstruction by pharyngeal metastasis. The cancer was diagnosed as pleomorphic carcinoma in an autopsy. Viable lung tumor cells, which were resistant to radiotherapy, and the pharyngeal metastasis had mesenchymal phenotypes and expressed ZEB1 but not SNAI1. These observations indicated that ZEB1-associated epithelial-mesenchymal transition has malignant features including resistance to radiotherapy and aggressive metastatic potential. ZEB1-associated EMT may be an important mechanism to understand the pathophysiology of pleomorphic carcinoma. Keywords: Pulmonary pleomorphic carcinoma, Epithelial-mesenchymal transition (EMT), ZEB1
url http://www.sciencedirect.com/science/article/pii/S2213007118300327
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