FOLATE CYCLE GENE POLYMORPHISM AND ENDOGENOUS PEPTIDES IN CHILDREN WITH COW’S MILK PROTEIN ALLERGY

• Main Authors: T. A. Shumatova, N. G. Prikhodchenko, E. S. Zernova, I. V. Efremova, S. N. Shishatskay, A. N. Ni, L. A. Grigoryan, E. Yu. Katenkova
• Format: Article
• Language: Russian
• Published: Ltd. “The National Academy of Pediatric Science and Innovation” 2017-01-01
• Series: Rossijskij Vestnik Perinatologii i Pediatrii
• Subjects: children; cow’s milk protein allergy; fatty acid-binding proteins; membrane permeability-increasing protein; folate cycle genes; eosinophil cationic protein; intestinal fatty acid-binding protein; liver fatty acid-binding protein; bactericidal/permeability-increasing protein
• Online Access: https://www.ped-perinatology.ru/jour/article/view/426
• ISSN: 1027-4065; 2500-2228

Folate cycle gene polymorphisms and the levels of endogenous antimicrobial peptides and proteins in the blood and coprofiltrates were studied in 45 children aged 3 to 12 months with cow’s milk protein allergy. The polymorphic variants of the MTHFR, MTRR, and MTR genes were shown to be considered as a risk factor for the development of allergy. There was a significant increase in the levels of zonulin, β-defensin 2, transthyretin, and eosinophil cationic protein in the coprofiltrates and in those of eotaxin, fatty acidbinding proteins, and membrane permeability-increasing protein in the serum (p<0.05). The finding can improve the diagnosis of the disease for a predictive purpose for the evaluation of the efficiency of performed therapy.