Effects of a single transient transfection of Ten-eleven translocation 1 catalytic domain on hepatocellular carcinoma.

Effects of a single transient transfection of Ten-eleven translocation 1 catalytic domain on hepatocellular carcinoma.

Tumor suppressor genes (TSGs), including Ten-eleven translocation 1 (TET1), are hypermethylated in hepatocellular carcinoma (HCC). TET1 catalytic domain (TET1-CD) induces genome-wide DNA demethylation to activate TSGs, but so far, anticancer effects of TET1-CD are unclear. Here we showed that after...

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Bibliographic Details
Main Authors: Yuying Liu, Hui Zhu, Zhenxue Zhang, Changchun Tu, Dongyuan Yao, Bin Wen, Ru Jiang, Xing Li, Pengfei Yi, Jiejie Zhan, Jiaping Hu, Jianwu Ding, Liping Jiang, Fanglin Zhang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0207139

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