Actividad opsonofagocítica contra meningococos del grupo B:¿Un correlato de protección adicional contra la enfermedad meningococica?

• Main Author: Audun Aase
• Format: Article
• Language: English
• Published: Finlay Ediciones 2009-08-01
• Series: VacciMonitor
• Subjects: Opsonophagocytic activity; correlate of protection; group B meningococci
• Online Access: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1025-028X2009000200010&lng=es&nrm=iso

Opsonophagocytic activity and serum bactericidal activity against group B meningococci were compared in sera from three vaccine groups given two different outer membrane vesicles vaccines separately or in combination. Opsonophagocytic activity defined more responders and revealed more cross-reactivity against heterologous strains than observed with serum bactericidal activity, and it showed the highest correlation with IgG-binding to live meningococci. Determination of opsonophagocytic activity may therefore be a valuable laboratory supplement to serum bactericidal activity for monitoring protection against group B meningococcal disease.