A Role for Exocytosis in the Spatial Regulationof Actin Organization

A Role for Exocytosis in the Spatial Regulationof Actin Organization

The efficient organization of the actin cytoskeleton is important for many cellular functions. However, how the local actin organization is regulated in a cell is not well understood. By using yeast mutants defective in actin organization and secretion, we demonstrated that exocytosis plays a role i...

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Main Authors: Xiang-Dong Gao, Stefan Albert
Format: Article
Language:English
Published: Hindawi Limited 2003-01-01
Series:The Scientific World Journal
Online Access:http://dx.doi.org/10.1100/tsw.2003.119
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spelling doaj-802ac93e1f1a437cb3f0eb49fcf03b8c2020-11-25T01:00:16ZengHindawi LimitedThe Scientific World Journal1537-744X2003-01-0131359136210.1100/tsw.2003.119A Role for Exocytosis in the Spatial Regulationof Actin OrganizationXiang-Dong Gao0Stefan Albert1Department of Cell and Developmental Biology, University of Pennsylvania, 421 Curie Boulevard, Philadelphia, PA 19104-6058, USADepartment of Cell and Developmental Biology, University of Pennsylvania, 421 Curie Boulevard, Philadelphia, PA 19104-6058, USAThe efficient organization of the actin cytoskeleton is important for many cellular functions. However, how the local actin organization is regulated in a cell is not well understood. By using yeast mutants defective in actin organization and secretion, we demonstrated that exocytosis plays a role in the spatial regulation of actin organization. Our findings suggest that the actin cytoskeleton, exocytosis, and perhaps endocytosis, may depend on each other for efficiency and reinforce each other.http://dx.doi.org/10.1100/tsw.2003.119
collection DOAJ
language English
format Article
sources DOAJ
author Xiang-Dong Gao
Stefan Albert
spellingShingle Xiang-Dong Gao
Stefan Albert
A Role for Exocytosis in the Spatial Regulationof Actin Organization
The Scientific World Journal
author_facet Xiang-Dong Gao
Stefan Albert
author_sort Xiang-Dong Gao
title A Role for Exocytosis in the Spatial Regulationof Actin Organization
title_short A Role for Exocytosis in the Spatial Regulationof Actin Organization
title_full A Role for Exocytosis in the Spatial Regulationof Actin Organization
title_fullStr A Role for Exocytosis in the Spatial Regulationof Actin Organization
title_full_unstemmed A Role for Exocytosis in the Spatial Regulationof Actin Organization
title_sort role for exocytosis in the spatial regulationof actin organization
publisher Hindawi Limited
series The Scientific World Journal
issn 1537-744X
publishDate 2003-01-01
description The efficient organization of the actin cytoskeleton is important for many cellular functions. However, how the local actin organization is regulated in a cell is not well understood. By using yeast mutants defective in actin organization and secretion, we demonstrated that exocytosis plays a role in the spatial regulation of actin organization. Our findings suggest that the actin cytoskeleton, exocytosis, and perhaps endocytosis, may depend on each other for efficiency and reinforce each other.
url http://dx.doi.org/10.1100/tsw.2003.119
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