Opposition between PKC Isoforms Regulates Histone Deimination and Neutrophil Extracellular Chromatin Release

Opposition between PKC Isoforms Regulates Histone Deimination and Neutrophil Extracellular Chromatin Release

In response to inflammation, neutrophils deiminate histones and externalize chromatin. Neutrophil extracellular traps (NETs) are an innate immune defense mechanism, yet NETs also may aggravate chronic inflammatory and autoimmune disorders. Activation of peptidylarginine deiminase IV (PAD4) is asso...

Full description

Bibliographic Details
Main Authors:	Marko eRadic, Indira eNeeli
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2013-02-01
Series:	Frontiers in Immunology
Subjects:	Inflammation Protein Kinase C pad4 NEtosis deimination
Online Access:	http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00038/full

Similar Items

Current Challenges and Limitations in Antibody-Based Detection of Citrullinated Histones
by: Indira Neeli, et al.
Published: (2016-11-01)

Post-Translational Protein Deimination Signatures in Serum and Serum-Extracellular Vesicles of <i>Bos taurus</i> Reveal Immune, Anti-Pathogenic, Anti-Viral, Metabolic and Cancer-Related Pathways for Deimination
by: Michael F. Criscitiello, et al.
Published: (2020-04-01)

Peptidylarginine Deiminase (PAD) and Post-Translational Protein Deimination—Novel Insights into Alveolata Metabolism, Epigenetic Regulation and Host–Pathogen Interactions
by: Árni Kristmundsson, et al.
Published: (2021-02-01)

Activation of PAD4 in NET formation
by: Amanda eRohrbach, et al.
Published: (2012-11-01)

Post-Translational Protein Deimination Signatures in Plasma and Plasma EVs of Reindeer (<i>Rangifer tarandus</i>)
by: Stefania D’Alessio, et al.
Published: (2021-03-01)

Extracellular Vesicles and Post-Translational Protein Deimination Signatures in Mollusca—The Blue Mussel (<i>Mytilus edulis</i>), Soft Shell Clam (<i>Mya arenaria</i>), Eastern Oyster (<i>Crassostrea virginica</i>) and Atlantic Jacknife Clam (<i>Ensis leei</i>)
by: Timothy J. Bowden, et al.
Published: (2020-11-01)

Protein Deimination Signatures in Plasma and Plasma-EVs and Protein Deimination in the Brain Vasculature in a Rat Model of Pre-Motor Parkinson’s Disease
by: Marco Sancandi, et al.
Published: (2020-04-01)

Clearance of Apoptotic Bodies, NETs and Biofilm DNA: Implications for Autoimmunity
by: Marko eRadic
Published: (2014-07-01)

Extracellular Vesicle Signatures and Post-Translational Protein Deimination in Purple Sea Urchin (<i>Strongylocentrotus purpuratus</i>) Coelomic Fluid—Novel Insights into Echinodermata Biology
by: Stefania D’Alessio, et al.
Published: (2021-09-01)

Post-Translational Deimination of Immunological and Metabolic Protein Markers in Plasma and Extracellular Vesicles of Naked Mole-Rat (<i>Heterocephalus glaber</i>)
by: Matthew E. Pamenter, et al.
Published: (2019-10-01)

Identification of macrophage extracellular trap-like structures in mammary gland adipose tissue: a preliminary study.
by: Sunish eMohanan, et al.
Published: (2013-03-01)

Deimination Protein Profiles in Alligator mississippiensis Reveal Plasma and Extracellular Vesicle-Specific Signatures Relating to Immunity, Metabolic Function, and Gene Regulation
by: Michael F. Criscitiello, et al.
Published: (2020-04-01)

Histone Acetylation Promotes Neutrophil Extracellular Trap Formation
by: Hussein J. Hamam, et al.
Published: (2019-01-01)

Thioredoxin Modulates Protein Arginine Deiminase 4 (PAD4)-Catalyzed Citrullination
by: Mitesh Nagar, et al.
Published: (2019-02-01)

Localized Delivery of Cl-Amidine From Electrospun Polydioxanone Templates to Regulate Acute Neutrophil NETosis: A Preliminary Evaluation of the PAD4 Inhibitor for Tissue Engineering
by: Allison E. Fetz, et al.
Published: (2018-03-01)

Protein Deimination and Extracellular Vesicle Profiles in Antarctic Seabirds
by: Richard A. Phillips, et al.
Published: (2020-01-01)

Peptidylarginine Deiminase Inhibitor Application, Using Cl-Amidine, PAD2, PAD3 and PAD4 Isozyme-Specific Inhibitors in Pancreatic Cancer Cells, Reveals Roles for PAD2 and PAD3 in Cancer Invasion and Modulation of Extracellular Vesicle Signatures
by: Pinar Uysal-Onganer, et al.
Published: (2021-01-01)

NETQUANT: Automated Quantification of Neutrophil Extracellular Traps
by: Tirthankar Mohanty, et al.
Published: (2018-01-01)

Hypertonic Saline Suppresses NADPH Oxidase-Dependent Neutrophil Extracellular Trap Formation and Promotes Apoptosis
by: Ajantha Nadesalingam, et al.
Published: (2018-03-01)

Putative Roles for Peptidylarginine Deiminases in COVID-19
by: Elif Damla Arisan, et al.
Published: (2020-06-01)

Neutrophil extracellular traps: diagnostic and prognostic value in COVID-19
by: D. V. Kassina, et al.
Published: (2020-09-01)

Acetylated Histones in Apoptotic Microparticles Drive the Formation of Neutrophil Extracellular Traps in Active Lupus Nephritis
by: Nils Rother, et al.
Published: (2017-09-01)

Neutrophil Extracellular Traps in the Establishment and Progression of Renal Diseases
by: Hector Salazar-Gonzalez, et al.
Published: (2019-08-01)

The Role of Neutrophil Extracellular Traps in Periodontitis
by: Jingyi Wang, et al.
Published: (2021-03-01)

MiR-155 Regulates PAD4-Dependent Formation of Neutrophil Extracellular Traps
by: Avin Hawez, et al.
Published: (2019-11-01)

Elevated Biomarkers of NETosis in the Serum of Pediatric Patients With Type 1 Diabetes and Their First-Degree Relatives
by: Adam Klocperk, et al.
Published: (2021-07-01)

An improved strategy to recover large fragments of functional human neutrophil extracellular traps
by: Lorena eBarrientos, et al.
Published: (2013-06-01)

Neutrophils discriminate between lipopolysaccharides of different bacterial sources and selectively release neutrophil extracellular traps
by: Elmar Pieterse, et al.
Published: (2016-11-01)

Glycans as Modulators for the Formation and Functional Properties of Neutrophil Extracellular Traps: Used by the Forces of Good and Evil
by: Kim F. Bornhöfft, et al.
Published: (2019-05-01)

Neutrophil Extracellular Traps, Antiphospholipid Antibodies and Treatment
by: Jessica Bravo-Barrera, et al.
Published: (2017-03-01)

Neutrophils: Orchestrators of the Malignant Phenotype
by: Brian E. Hsu, et al.
Published: (2020-08-01)

Neutrophil extracellular trap induced by HMGB1 exacerbates damages in the ischemic brain
by: Seung-Woo Kim, et al.
Published: (2019-06-01)

Production of Neutrophil Extracellular Traps Contributes to the Pathogenesis of Francisella tularemia
by: Sivasami Pulavendran, et al.
Published: (2020-04-01)

Neutrophils: Many Ways to Die
by: Erandi Pérez-Figueroa, et al.
Published: (2021-03-01)

PAD4 mediated histone hypercitrullination induces heterochromatin decondensation and chromatin unfolding to form neutrophil extracellular trap-like structures
by: Marc eLeshner, et al.
Published: (2012-10-01)

Short-Term Fever-Range Hyperthermia Accelerates NETosis and Reduces Pro-inflammatory Cytokine Secretion by Human Neutrophils
by: Irene A. Keitelman, et al.
Published: (2019-10-01)

Entamoeba histolytica Induce Signaling via Raf/MEK/ERK for Neutrophil Extracellular Trap (NET) Formation
by: Zayda Fonseca, et al.
Published: (2018-07-01)

Andrographolide Ameliorates Rheumatoid Arthritis by Regulating the Apoptosis–NETosis Balance of Neutrophils
by: Xiaohong Li, et al.
Published: (2019-10-01)

Sera from patients with active pulmonary tuberculosis and their household contacts induce nuclear changes in neutrophils
by: Juárez-Ortega M, et al.
Published: (2018-10-01)

Role of neutrophil dysfunction in the pathogenesis of systemic lupus erythematosus
by: E V Smirnova, et al.
Published: (2017-12-01)

Cannot write session to /tmp/vufind_sessions/sess_v6gn18fb584071s6vkomgcvsvu