A Rare Human Syndrome Provides Genetic Evidence that WNT Signaling Is Required for Reprogramming of Fibroblasts to Induced Pluripotent Stem Cells
Summary: WNT signaling promotes the reprogramming of somatic cells to an induced pluripotent state. We provide genetic evidence that WNT signaling is a requisite step during the induction of pluripotency. Fibroblasts from individuals with focal dermal hypoplasia (FDH), a rare genetic syndrome caused...
Main Authors: | Jason Ross, Julia Busch, Ellen Mintz, Damian Ng, Alexandra Stanley, David Brafman, V. Reid Sutton, Ignatia Van den Veyver, Karl Willert |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2014-12-01
|
Series: | Cell Reports |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124714009188 |
Similar Items
-
The WNT target SP5 negatively regulates WNT transcriptional programs in human pluripotent stem cells
by: Ian J. Huggins, et al.
Published: (2017-10-01) -
Profiling and quantification of pluripotency reprogramming reveal that WNT pathways and cell morphology have to be reprogramed extensively
by: Kejin Hu, et al.
Published: (2020-05-01) -
EXPRESSION OF PLURIPOTENCY MARKERS IN REPROGRAMMING WITH TRANSPOSON SYSTEM MURINE FIBROBLASTS
by: S. V. Malysheva, et al.
Published: (2013-10-01) -
Reprogramming human endometrial fibroblast into induced pluripotent stem cells
by: Yi-Jen Chen, et al.
Published: (2012-03-01) -
Wnt Inhibition Facilitates RNA-Mediated Reprogramming of Human Somatic Cells to Naive Pluripotency
by: Nicholas Bredenkamp, et al.
Published: (2019-12-01)