The Two-Faced Role of SIRT6 in Cancer

The Two-Faced Role of SIRT6 in Cancer

Sirtuin 6 (SIRT6) is a NAD<sup>+</sup>-dependent nuclear deacylase and mono-ADP-ribosylase with a wide spectrum of substrates. Through its pleiotropic activities, SIRT6 modulates either directly or indirectly key processes linked to cell fate determination and oncogenesis such as DNA dam...

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Bibliographic Details
Main Authors:	Francesco Fiorentino, Vincenzo Carafa, Gregorio Favale, Lucia Altucci, Antonello Mai, Dante Rotili
Format:	Article
Language:	English
Published:	MDPI AG 2021-03-01
Series:	Cancers
Subjects:	NAD<sup>+</sup>-dependent deacylases cell death modulation SIRT6 modulators cancer epigenetics
Online Access:	https://www.mdpi.com/2072-6694/13/5/1156

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