Development of IL-15/IL-15Rα sushi domain-IgG4 Fc complexes in Pichia pastoris with potent activities and prolonged half-lives

Development of IL-15/IL-15Rα sushi domain-IgG4 Fc complexes in Pichia pastoris with potent activities and prolonged half-lives

Abstract Background Interleukin-15 (IL-15) is a critical cytokine for the development, proliferation, and function of natural killer (NK) cells, NKT cells, and CD8+ memory T cells and has become one of the most promising protein molecules for the treatment of cancer and viral diseases. However, ther...

Full description

Bibliographic Details
Main Authors: Huan Xu, Mingyang Shi, Changsheng Shao, Hao Li, Jing Wu, Yin Yu, Fang Fang, Yugang Guo, Weihua Xiao
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Microbial Cell Factories
Subjects:
Interleukin-15
Superagonists
Immunotherapy
Half-life
NK
Pichia pastoris
Online Access:https://doi.org/10.1186/s12934-021-01605-3

Internet

https://doi.org/10.1186/s12934-021-01605-3

Similar Items