The GCN5-CITED2-PKA signalling module controls hepatic glucose metabolism through a cAMP-induced substrate switch

The GCN5-CITED2-PKA signalling module controls hepatic glucose metabolism through a cAMP-induced substrate switch

GCN5 inhibits hepatic gluconeogenesis through acetylation of PGC-1α. Here the authors show that GCN5 also activates hepatic gluconeogenesis by acetylating histone H3K9, and that the affinity of GCN5 for its different substrates is regulated via phosphorylation at S275 by PKA in a CITED2-dependent ma...

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Main Authors: Mashito Sakai, Tomoko Tujimura-Hayakawa, Takashi Yagi, Hiroyuki Yano, Masaru Mitsushima, Hiroyuki Unoki-Kubota, Yasushi Kaburagi, Hiroshi Inoue, Yoshiaki Kido, Masato Kasuga, Michihiro Matsumoto
Format: Article
Language:English
Published: Nature Publishing Group 2016-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms13147
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spelling doaj-8001c64b252745a788bee1e6cfee26e32021-05-11T10:48:38ZengNature Publishing GroupNature Communications2041-17232016-11-017111510.1038/ncomms13147The GCN5-CITED2-PKA signalling module controls hepatic glucose metabolism through a cAMP-induced substrate switchMashito Sakai0Tomoko Tujimura-Hayakawa1Takashi Yagi2Hiroyuki Yano3Masaru Mitsushima4Hiroyuki Unoki-Kubota5Yasushi Kaburagi6Hiroshi Inoue7Yoshiaki Kido8Masato Kasuga9Michihiro Matsumoto10Department of Molecular Metabolic Regulation, Diabetes Research Center, Research Institute, National Center for Global Health and MedicineDepartment of Molecular Metabolic Regulation, Diabetes Research Center, Research Institute, National Center for Global Health and MedicineDepartment of Molecular Metabolic Regulation, Diabetes Research Center, Research Institute, National Center for Global Health and MedicineDepartment of Molecular Metabolic Regulation, Diabetes Research Center, Research Institute, National Center for Global Health and MedicineDepartment of Molecular Metabolic Regulation, Diabetes Research Center, Research Institute, National Center for Global Health and MedicineDepartment of Diabetic Complications, Diabetes Research Center, Research Institute, National Center for Global Health and MedicineDepartment of Diabetic Complications, Diabetes Research Center, Research Institute, National Center for Global Health and MedicineMetabolism and Nutrition Research Unit, Innovative Integrated Bio-research Core, Institute for Frontier Science Initiative, Kanazawa UniversityDivision of Medical Chemistry, Department of Metabolism and Disease, Kobe University Graduate School of Health SciencesNational Center for Global Health and MedicineDepartment of Molecular Metabolic Regulation, Diabetes Research Center, Research Institute, National Center for Global Health and MedicineGCN5 inhibits hepatic gluconeogenesis through acetylation of PGC-1α. Here the authors show that GCN5 also activates hepatic gluconeogenesis by acetylating histone H3K9, and that the affinity of GCN5 for its different substrates is regulated via phosphorylation at S275 by PKA in a CITED2-dependent manner.https://doi.org/10.1038/ncomms13147
collection DOAJ
language English
format Article
sources DOAJ
author Mashito Sakai
Tomoko Tujimura-Hayakawa
Takashi Yagi
Hiroyuki Yano
Masaru Mitsushima
Hiroyuki Unoki-Kubota
Yasushi Kaburagi
Hiroshi Inoue
Yoshiaki Kido
Masato Kasuga
Michihiro Matsumoto
spellingShingle Mashito Sakai
Tomoko Tujimura-Hayakawa
Takashi Yagi
Hiroyuki Yano
Masaru Mitsushima
Hiroyuki Unoki-Kubota
Yasushi Kaburagi
Hiroshi Inoue
Yoshiaki Kido
Masato Kasuga
Michihiro Matsumoto
The GCN5-CITED2-PKA signalling module controls hepatic glucose metabolism through a cAMP-induced substrate switch
Nature Communications
author_facet Mashito Sakai
Tomoko Tujimura-Hayakawa
Takashi Yagi
Hiroyuki Yano
Masaru Mitsushima
Hiroyuki Unoki-Kubota
Yasushi Kaburagi
Hiroshi Inoue
Yoshiaki Kido
Masato Kasuga
Michihiro Matsumoto
author_sort Mashito Sakai
title The GCN5-CITED2-PKA signalling module controls hepatic glucose metabolism through a cAMP-induced substrate switch
title_short The GCN5-CITED2-PKA signalling module controls hepatic glucose metabolism through a cAMP-induced substrate switch
title_full The GCN5-CITED2-PKA signalling module controls hepatic glucose metabolism through a cAMP-induced substrate switch
title_fullStr The GCN5-CITED2-PKA signalling module controls hepatic glucose metabolism through a cAMP-induced substrate switch
title_full_unstemmed The GCN5-CITED2-PKA signalling module controls hepatic glucose metabolism through a cAMP-induced substrate switch
title_sort gcn5-cited2-pka signalling module controls hepatic glucose metabolism through a camp-induced substrate switch
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2016-11-01
description GCN5 inhibits hepatic gluconeogenesis through acetylation of PGC-1α. Here the authors show that GCN5 also activates hepatic gluconeogenesis by acetylating histone H3K9, and that the affinity of GCN5 for its different substrates is regulated via phosphorylation at S275 by PKA in a CITED2-dependent manner.
url https://doi.org/10.1038/ncomms13147
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