Premature expression of Foxp3 in double-negative thymocytes.

Premature expression of Foxp3 in double-negative thymocytes.

Peripheral immune regulation depends on the generation of thymic-derived regulatory T (tTreg) cells to maintain self-tolerance and to counterbalance overshooting immune responses. The expression of the Treg lineage defining transcription factor Foxp3 in developing tTreg cells depends on TCR signalin...

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Bibliographic Details
Main Authors: Melanie M Barra, David M Richards, Ann-Cathrin Hofer, Michael Delacher, Markus Feuerer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4433242?pdf=render

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