Detecting protein and DNA/RNA structures in cryo-EM maps of intermediate resolution using deep learning

Detecting protein and DNA/RNA structures in cryo-EM maps of intermediate resolution using deep learning

It is challenging to extract structural information from EM density maps at intermediate or low resolutions. Here, the authors present Emap2sec+, a program for detecting nucleotides and protein secondary structures in EM density maps at 5 to 10 Å resolution.

Bibliographic Details
Main Authors: Xiao Wang, Eman Alnabati, Tunde W. Aderinwale, Sai Raghavendra Maddhuri Venkata Subramaniya, Genki Terashi, Daisuke Kihara
Format: Article
Language:English
Published: Nature Publishing Group 2021-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-22577-3
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spelling doaj-7fdf26b480c34d9188c773c5752a3afa2021-04-18T11:13:19ZengNature Publishing GroupNature Communications2041-17232021-04-011211910.1038/s41467-021-22577-3Detecting protein and DNA/RNA structures in cryo-EM maps of intermediate resolution using deep learningXiao Wang0Eman Alnabati1Tunde W. Aderinwale2Sai Raghavendra Maddhuri Venkata Subramaniya3Genki Terashi4Daisuke Kihara5Department of Computer Science, Purdue UniversityDepartment of Computer Science, Purdue UniversityDepartment of Computer Science, Purdue UniversityDepartment of Computer Science, Purdue UniversityDepartment of Biological Sciences, Purdue UniversityDepartment of Computer Science, Purdue UniversityIt is challenging to extract structural information from EM density maps at intermediate or low resolutions. Here, the authors present Emap2sec+, a program for detecting nucleotides and protein secondary structures in EM density maps at 5 to 10 Å resolution.https://doi.org/10.1038/s41467-021-22577-3
collection DOAJ
language English
format Article
sources DOAJ
author Xiao Wang
Eman Alnabati
Tunde W. Aderinwale
Sai Raghavendra Maddhuri Venkata Subramaniya
Genki Terashi
Daisuke Kihara
spellingShingle Xiao Wang
Eman Alnabati
Tunde W. Aderinwale
Sai Raghavendra Maddhuri Venkata Subramaniya
Genki Terashi
Daisuke Kihara
Detecting protein and DNA/RNA structures in cryo-EM maps of intermediate resolution using deep learning
Nature Communications
author_facet Xiao Wang
Eman Alnabati
Tunde W. Aderinwale
Sai Raghavendra Maddhuri Venkata Subramaniya
Genki Terashi
Daisuke Kihara
author_sort Xiao Wang
title Detecting protein and DNA/RNA structures in cryo-EM maps of intermediate resolution using deep learning
title_short Detecting protein and DNA/RNA structures in cryo-EM maps of intermediate resolution using deep learning
title_full Detecting protein and DNA/RNA structures in cryo-EM maps of intermediate resolution using deep learning
title_fullStr Detecting protein and DNA/RNA structures in cryo-EM maps of intermediate resolution using deep learning
title_full_unstemmed Detecting protein and DNA/RNA structures in cryo-EM maps of intermediate resolution using deep learning
title_sort detecting protein and dna/rna structures in cryo-em maps of intermediate resolution using deep learning
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2021-04-01
description It is challenging to extract structural information from EM density maps at intermediate or low resolutions. Here, the authors present Emap2sec+, a program for detecting nucleotides and protein secondary structures in EM density maps at 5 to 10 Å resolution.
url https://doi.org/10.1038/s41467-021-22577-3
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AT emanalnabati detectingproteinanddnarnastructuresincryoemmapsofintermediateresolutionusingdeeplearning
AT tundewaderinwale detectingproteinanddnarnastructuresincryoemmapsofintermediateresolutionusingdeeplearning
AT sairaghavendramaddhurivenkatasubramaniya detectingproteinanddnarnastructuresincryoemmapsofintermediateresolutionusingdeeplearning
AT genkiterashi detectingproteinanddnarnastructuresincryoemmapsofintermediateresolutionusingdeeplearning
AT daisukekihara detectingproteinanddnarnastructuresincryoemmapsofintermediateresolutionusingdeeplearning
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