Gastrointestinal symptoms in the course of COVID-19
COVID-19 is an infectious disease caused by novel coronavirus SARS-CoV-2, a betacoronavirus comprised of single-stranded ribonucleic acid (RNA), the first time reported in December 2019 as pneumonia with unknown etiology in Wuhan City in China. It is a very important current problem for public healt...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Index Copernicus International S.A.
2020-11-01
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| Series: | Postępy Higieny i Medycyny Doświadczalnej |
| Subjects: | |
| Online Access: | http://phmd.pl/gicid/01.3001.0014.5459 |
| Summary: | COVID-19 is an infectious disease caused by novel coronavirus SARS-CoV-2, a betacoronavirus
comprised of single-stranded ribonucleic acid (RNA), the first time reported in December
2019 as pneumonia with unknown etiology in Wuhan City in China. It is a very important
current problem for public health worldwide. A typical clinical course includes dyspnoea,
dry cough and fever. In the presented paper we conducted the literature review and described
the most important facts within the current state of knowledge about symptomatology
and pathophysiology of gastrointestinal dysfunction in the course of COVID-19. Data about
prevalence of gastrointestinal symptoms in the course of COVID-19 show wide divergence in
the cited literature. Generally, the most common reported digestive symptoms were loss of
appetite, nausea and vomiting. Liver injury in the course of COVID-19 is also an important
and not well understood problem. The virus has high affinity to cells containing angiotensin-
-converting enzyme 2 (ACE2) protein. Digestive symptoms of COVID-19 may be associated with
ACE2 expression in epithelial cells in upper oesophagus, ileum and colon. Previous scientific
reports have elucidated the role of ACE2 in modulating intestinal inflammation and diarrhoea.
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| ISSN: | 0032-5449 1732-2693 |