The Anti-apoptosis Effects of Daidzein in the Brain of D-Galactose Treated Mice

The Anti-apoptosis Effects of Daidzein in the Brain of D-Galactose Treated Mice

The purpose of this study was to explore the neuroprotective effects of daidzein on the apoptotic pathway in the hippocampus and cortex of D-galactose treated mice. For this purpose we have examined the expression of bcl-2 mRNA, bax mRNA and caspase-3 in the hippocampus and cortex of D-galactose-tre...

Full description

Bibliographic Details
Main Authors: Xiang-bin Hu, Qing Chang, Xiao-wan Zhu, Bao-ping Han, Yan-qiu Zhang, Yuan-lin Zheng, Zhen Mao
Format: Article
Language:English
Published: MDPI AG 2007-07-01
Series:Molecules
Subjects:
Daidzein
apoptosis
caspase 3
bcl-2
bax
Online Access:http://www.mdpi.com/1420-3049/12/7/1455/
Description
Summary:The purpose of this study was to explore the neuroprotective effects of daidzein on the apoptotic pathway in the hippocampus and cortex of D-galactose treated mice. For this purpose we have examined the expression of bcl-2 mRNA, bax mRNA and caspase-3 in the hippocampus and cortex of D-galactose-treated mice after fed with 10 or 5 mg/kg of daidzein. The results of in situ hybridization experiments indicate that daidzein could help increase the transcriptions of bcl-2 and decrease the transcriptions of bax in those brain regions of D-galactose-treated mice. Furthermore, immunohistochemical studies showed that daidzein could reduce the expression of caspase-3 in both brain regions. These results suggest that daidzein in soybean can inhibit the D-gal induced apoptosis via Bcl-2/Bax apoptotic pathway and be a potential medical candidate for neurodegeneration therapy.
ISSN:1420-3049

Similar Items