IL-2-Agonist-Induced IFN-γ Exacerbates Systemic Anaphylaxis in Food Allergen-Sensitized Mice

IL-2-Agonist-Induced IFN-γ Exacerbates Systemic Anaphylaxis in Food Allergen-Sensitized Mice

Food allergies are common, costly and potentially life-threatening disorders. They are driven by Th2, but inhibited by Th1 reactions. There is also evidence indicating that IL-2 agonist treatment inhibits allergic sensitization through expansion of regulatory T cells. Here, we tested the impact of a...

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Bibliographic Details
Main Authors: Christopher W.M. Link, Christina N. Rau, Christopher C. Udoye, Mohab Ragab, Rabia Ü. Korkmaz, Sara Comdühr, Ann-Katrin Clauder, Timo Lindemann, Britta Frehse, Katharina Hofmann, Larissa N. Almeida, Yves Laumonnier, Asmaa El Beidaq, Fred D. Finkelman, Rudolf A. Manz
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Immunology
Subjects:
food allergy
IL-2
IFN-γ
anaphylaxis
murine model
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.596772/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.596772/full

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