The Amino Acid Changes T55A, A273P and R277C in the Beta-Lactamase CTX-M-14 Render <i>E. coli</i> Resistant to the Antibiotic Nitrofurantoin, a First-Line Treatment of Urinary Tract Infections

The Amino Acid Changes T55A, A273P and R277C in the Beta-Lactamase CTX-M-14 Render <i>E. coli</i> Resistant to the Antibiotic Nitrofurantoin, a First-Line Treatment of Urinary Tract Infections

The antibiotic nitrofurantoin is a furan flanked by a nitro group and a hydantoin ring. It is used to treat lower urinary tract infections (UTIs) that have a lifetime incidence of 50−60% in adult women. UTIs are typically caused by uropathogenic <i>Escherichia coli</i> (UPEC), which are...

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Bibliographic Details
Main Authors: Yasir Edowik, Thomas Caspari, Hugh Merfyn Williams
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Microorganisms
Subjects:
antibiotic resistance
beta-lactamase
nitrofurantoin
urinary tract infection
CTX-M
Online Access:https://www.mdpi.com/2076-2607/8/12/1983

Internet

https://www.mdpi.com/2076-2607/8/12/1983

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