Doxycycline reduces MMP-2 activity and inhibits invasion of 12Z epithelial endometriotic cells as well as MMP-2 and -9 activity in primary endometriotic stromal cells in vitro

Doxycycline reduces MMP-2 activity and inhibits invasion of 12Z epithelial endometriotic cells as well as MMP-2 and -9 activity in primary endometriotic stromal cells in vitro

Abstract Background Matrix metalloproteinases (MMPs), especially the gelatinases MMP-2 and MMP-9, play a crucial role in the pathogenesis of endometriosis by enabling invasion. Doxycycline is a well-tolerated antibiotic and a potent MMP-inhibitor in subantimicrobial doses. Methods Gelatin zymography...

Full description

Bibliographic Details
Main Authors: Eleftherios P. Samartzis, Daniel Fink, Manuel Stucki, Patrick Imesch
Format: Article
Language:English
Published: BMC 2019-04-01
Series:Reproductive Biology and Endocrinology
Subjects:
Endometriosis
Cell culture
Extracellular matrix
Progesterone
Female reproductive tract
Online Access:http://link.springer.com/article/10.1186/s12958-019-0481-z

Similar Items

Similar Items