GENETIC FACTORS INDUCING DISTURBED REGULATION OF ANGIOGENESIS IN DIABETES MELLITUS TYPE 2

• Main Authors: V. I. Konenkov, A. V. Shevchenko, V. F. Prokof’ev, V. V. Klimontov, M. A. Korolev, O. N. Fazulina, S. A. Lapsina, E. A. Koroleva
• Format: Article
• Language: Russian
• Published: SPb RAACI 2014-07-01
• Series: Medicinskaâ Immunologiâ
• Subjects: matrix metalloproteinases; vegf; cytokines; gene polymorphism; diabetes mellitus type 2
• Online Access: https://www.mimmun.ru/mimmun/article/view/547
• ISSN: 1563-0625; 2313-741X

Abstract. The article includes results of studying frequency distributions of polymorphic genotypes forsome genes regulating angiogenesis, i.e., MMP and VEGF, and their combinations with genotypes of some cytokines showing pro-angiogenic activity in patients with diabetes mellitus type 2 (DM2) and healthy controls. Angiogenesis-inducing MMP2-MMP9-VEGF genotype constellations have been shown to be more common in DM patients, thus presumably causing an imbalance between activation and suppression signals, being connected with C alleles of VEGF and MMP2, as well as with harboring of MMP9 C allele. Certain genotypes of IL-1B, IL-4, IL-10, IL-6, and TNFA, along with MMP and VEGF variants are more common within combined genetic patterns in DM patients. It is suggested that allelic combination studies of angiogenesis- and inflammation-regulating genes are necessary for understanding the DM2 pathogenesis, taking into account genetic control mechanisms influencing basic production levels of these regulatory factors.