The state of blood lymphocyte metabolism in Graves' disease patients in the treatment course

• Format: Article
• Language: Russian
• Published: Endocrinology Research Centre 2010-09-01
• Series: Клиническая и экспериментальная тиреоидология
• Subjects: graves' disease; metabolism; lymphocyte
• Online Access: https://cet-endojournals.ru/ket/article/viewFile/4282/2419

This article is about the research of the blood lymphocyte metabolism in 35 women with Graves' disease (GD). The definition of thyroid (fO4, O3), thyro1tropic hormones, antibodies against thyroid peroxidase and blood lymphocyte NAD(P)1dependent dehydrogenases was spent before the beginning of treatment and later 1 and 3 months receip1 tion of thiamazolc. The thyroid hormones concen1tration in GD patients is come to normal after 3 months of treat1 ment. The lympho1cyte metabolism is characterized by the increase level of macromolecular synthesis and antiox1 idant ability in cells, high efficiency malate1aspartate shuttle, and the increase level amino1acid exchange in GD patients throughout all period of re1search. Also in GD patients it is broken endocrine regulation of lymphocyte me1 tabolism, one point the correlation reduction between thyroid hormones concentra1tion and enzyme indicators.