Tethering in RNA: An RNA-Binding Fragment Discovery Tool

Tethering in RNA: An RNA-Binding Fragment Discovery Tool

Tethering has been extensively used to study small molecule interactions with proteins through reversible disulfide bond forming reactions to cysteine residues. We describe the adaptation of Tethering to the study of small molecule binding to RNA using a thiol-containing adenosine analog (ASH). Amon...

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Bibliographic Details
Main Authors: Kiet Tran, Michelle R. Arkin, Peter A. Beal
Format: Article
Language:English
Published: MDPI AG 2015-03-01
Series:Molecules
Subjects:
Tethering
miRNA
nucleoside analog
Online Access:http://www.mdpi.com/1420-3049/20/3/4148

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