The effect of pharmacological inhibition of Serine Proteases on neuronal networks in vitro

The effect of pharmacological inhibition of Serine Proteases on neuronal networks in vitro

Neurons are embedded in an extracellular matrix (ECM), which functions both as a scaffold and as a regulator of neuronal function. The ECM is in turn dynamically altered through the action of serine proteases, which break down its constituents. This pathway has been implicated in the regulation of s...

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Bibliographic Details
Main Authors: Sebastiaan Van De Vijver, Stephan Missault, Jeroen Van Soom, Pieter Van Der Veken, Koen Augustyns, Jurgen Joossens, Stefanie Dedeurwaerdere, Michele Giugliano
Format: Article
Language:English
Published: PeerJ Inc. 2019-04-01
Series:PeerJ
Subjects:
Extracellular matrix
Microelectrode arrays
Neurons
Network activity
Serine proteases
Patch-clamp
Online Access:https://peerj.com/articles/6796.pdf

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