Thiamine deficiency contributes to synapse and neural circuit defects

Thiamine deficiency contributes to synapse and neural circuit defects

Abstract Background The previous studies have demonstrated the reduction of thiamine diphosphate is specific to Alzheimer’s disease (AD) and causal factor of brain glucose hypometabolism, which is considered as a neurodegenerative index of AD and closely correlates with the degree of cognitive impai...

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Bibliographic Details
Main Authors: Qiujian Yu, Huimin Liu, Shaoming Sang, Lulan Chen, Yingya Zhao, Yun Wang, Chunjiu Zhong
Format: Article
Language:English
Published: BMC 2018-09-01
Series:Biological Research
Subjects:
Thiamine deficiency
Synaptic dysfunction
Amyloid-β
Alzheimer’s disease
Online Access:http://link.springer.com/article/10.1186/s40659-018-0184-5

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