Toward Engineering Synthetic Microbial Metabolism

Toward Engineering Synthetic Microbial Metabolism

The generation of well-characterized parts and the formulation of biological design principles in synthetic biology are laying the foundation for more complex and advanced microbial metabolic engineering. Improvements in de novo DNA synthesis and codon-optimization alone are already contributing to...

Full description

Bibliographic Details
Main Authors: George H. McArthur, Stephen S. Fong
Format: Article
Language:English
Published: Hindawi Limited 2010-01-01
Series:Journal of Biomedicine and Biotechnology
Online Access:http://dx.doi.org/10.1155/2010/459760
id doaj-7f9b32bc7be64f1fbf46085d80b98e20
record_format Article
spelling doaj-7f9b32bc7be64f1fbf46085d80b98e202020-11-25T01:53:46ZengHindawi LimitedJournal of Biomedicine and Biotechnology1110-72431110-72512010-01-01201010.1155/2010/459760459760Toward Engineering Synthetic Microbial MetabolismGeorge H. McArthur0Stephen S. Fong1Department of Chemical and Life Science Engineering, Virginia Commonwealth University, 601 W. Main Street, Richmond, VA 23284-3028, USADepartment of Chemical and Life Science Engineering, Virginia Commonwealth University, 601 W. Main Street, Richmond, VA 23284-3028, USAThe generation of well-characterized parts and the formulation of biological design principles in synthetic biology are laying the foundation for more complex and advanced microbial metabolic engineering. Improvements in de novo DNA synthesis and codon-optimization alone are already contributing to the manufacturing of pathway enzymes with improved or novel function. Further development of analytical and computer-aided design tools should accelerate the forward engineering of precisely regulated synthetic pathways by providing a standard framework for the predictable design of biological systems from well-characterized parts. In this review we discuss the current state of synthetic biology within a four-stage framework (design, modeling, synthesis, analysis) and highlight areas requiring further advancement to facilitate true engineering of synthetic microbial metabolism.http://dx.doi.org/10.1155/2010/459760
collection DOAJ
language English
format Article
sources DOAJ
author George H. McArthur
Stephen S. Fong
spellingShingle George H. McArthur
Stephen S. Fong
Toward Engineering Synthetic Microbial Metabolism
Journal of Biomedicine and Biotechnology
author_facet George H. McArthur
Stephen S. Fong
author_sort George H. McArthur
title Toward Engineering Synthetic Microbial Metabolism
title_short Toward Engineering Synthetic Microbial Metabolism
title_full Toward Engineering Synthetic Microbial Metabolism
title_fullStr Toward Engineering Synthetic Microbial Metabolism
title_full_unstemmed Toward Engineering Synthetic Microbial Metabolism
title_sort toward engineering synthetic microbial metabolism
publisher Hindawi Limited
series Journal of Biomedicine and Biotechnology
issn 1110-7243
1110-7251
publishDate 2010-01-01
description The generation of well-characterized parts and the formulation of biological design principles in synthetic biology are laying the foundation for more complex and advanced microbial metabolic engineering. Improvements in de novo DNA synthesis and codon-optimization alone are already contributing to the manufacturing of pathway enzymes with improved or novel function. Further development of analytical and computer-aided design tools should accelerate the forward engineering of precisely regulated synthetic pathways by providing a standard framework for the predictable design of biological systems from well-characterized parts. In this review we discuss the current state of synthetic biology within a four-stage framework (design, modeling, synthesis, analysis) and highlight areas requiring further advancement to facilitate true engineering of synthetic microbial metabolism.
url http://dx.doi.org/10.1155/2010/459760
work_keys_str_mv AT georgehmcarthur towardengineeringsyntheticmicrobialmetabolism
AT stephensfong towardengineeringsyntheticmicrobialmetabolism
_version_ 1724989205328691200

Similar Items