Involvement of cigarette smoke-induced epithelial cell ferroptosis in COPD pathogenesis
Altered iron homeostasis resulting in excessive oxidative stress has been implicated in smoke-induced lung diseases. Here the authors show that ferroptosis of lung epithelial cells, potentially resulting from excessive ferritinophagy, is involved in the pathogenesis of COPD.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2019-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-10991-7 |
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doaj-7f973dabdbee4e05bfa82fda5c334da72021-05-11T12:09:55ZengNature Publishing GroupNature Communications2041-17232019-07-0110111410.1038/s41467-019-10991-7Involvement of cigarette smoke-induced epithelial cell ferroptosis in COPD pathogenesisMasahiro Yoshida0Shunsuke Minagawa1Jun Araya2Taro Sakamoto3Hiromichi Hara4Kazuya Tsubouchi5Yusuke Hosaka6Akihiro Ichikawa7Nayuta Saito8Tsukasa Kadota9Nahoko Sato10Yusuke Kurita11Kenji Kobayashi12Saburo Ito13Hirohumi Utsumi14Hiroshi Wakui15Takanori Numata16Yumi Kaneko17Shohei Mori18Hisatoshi Asano19Makoto Yamashita20Makoto Odaka21Toshiaki Morikawa22Katsutoshi Nakayama23Takeo Iwamoto24Hirotaka Imai25Kazuyoshi Kuwano26Division of Respiratory Diseases, Department of Internal Medicine, Jikei University School of MedicineDivision of Respiratory Diseases, Department of Internal Medicine, Jikei University School of MedicineDivision of Respiratory Diseases, Department of Internal Medicine, Jikei University School of MedicineLaboratory of Hygienic Chemistry and Medicinal Research Laboratories, School of Pharmaceutical Sciences, Kitasato UniversityDivision of Respiratory Diseases, Department of Internal Medicine, Jikei University School of MedicineDivision of Respiratory Diseases, Department of Internal Medicine, Jikei University School of MedicineDivision of Respiratory Diseases, Department of Internal Medicine, Jikei University School of MedicineDivision of Respiratory Diseases, Department of Internal Medicine, Jikei University School of MedicineDivision of Respiratory Diseases, Department of Internal Medicine, Jikei University School of MedicineDivision of Respiratory Diseases, Department of Internal Medicine, Jikei University School of MedicineDivision of Respiratory Diseases, Department of Internal Medicine, Jikei University School of MedicineDivision of Respiratory Diseases, Department of Internal Medicine, Jikei University School of MedicineDivision of Respiratory Diseases, Department of Internal Medicine, Jikei University School of MedicineDivision of Respiratory Diseases, Department of Internal Medicine, Jikei University School of MedicineDivision of Respiratory Diseases, Department of Internal Medicine, Jikei University School of MedicineDivision of Respiratory Diseases, Department of Internal Medicine, Jikei University School of MedicineDivision of Respiratory Diseases, Department of Internal Medicine, Jikei University School of MedicineDivision of Chest Diseases, Department of Surgery, Jikei University School of MedicineDivision of Chest Diseases, Department of Surgery, Jikei University School of MedicineDivision of Chest Diseases, Department of Surgery, Jikei University School of MedicineDivision of Chest Diseases, Department of Surgery, Jikei University School of MedicineDivision of Chest Diseases, Department of Surgery, Jikei University School of MedicineDivision of Chest Diseases, Department of Surgery, Jikei University School of MedicineDivision of Respiratory Diseases, Department of Internal Medicine, Jikei University School of MedicineDivision of Molecular Cell Biology, Core Research Facilities for Basic Science, Jikei University School of MedicineLaboratory of Hygienic Chemistry and Medicinal Research Laboratories, School of Pharmaceutical Sciences, Kitasato UniversityDivision of Respiratory Diseases, Department of Internal Medicine, Jikei University School of MedicineAltered iron homeostasis resulting in excessive oxidative stress has been implicated in smoke-induced lung diseases. Here the authors show that ferroptosis of lung epithelial cells, potentially resulting from excessive ferritinophagy, is involved in the pathogenesis of COPD.https://doi.org/10.1038/s41467-019-10991-7 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Masahiro Yoshida Shunsuke Minagawa Jun Araya Taro Sakamoto Hiromichi Hara Kazuya Tsubouchi Yusuke Hosaka Akihiro Ichikawa Nayuta Saito Tsukasa Kadota Nahoko Sato Yusuke Kurita Kenji Kobayashi Saburo Ito Hirohumi Utsumi Hiroshi Wakui Takanori Numata Yumi Kaneko Shohei Mori Hisatoshi Asano Makoto Yamashita Makoto Odaka Toshiaki Morikawa Katsutoshi Nakayama Takeo Iwamoto Hirotaka Imai Kazuyoshi Kuwano |
| spellingShingle |
Masahiro Yoshida Shunsuke Minagawa Jun Araya Taro Sakamoto Hiromichi Hara Kazuya Tsubouchi Yusuke Hosaka Akihiro Ichikawa Nayuta Saito Tsukasa Kadota Nahoko Sato Yusuke Kurita Kenji Kobayashi Saburo Ito Hirohumi Utsumi Hiroshi Wakui Takanori Numata Yumi Kaneko Shohei Mori Hisatoshi Asano Makoto Yamashita Makoto Odaka Toshiaki Morikawa Katsutoshi Nakayama Takeo Iwamoto Hirotaka Imai Kazuyoshi Kuwano Involvement of cigarette smoke-induced epithelial cell ferroptosis in COPD pathogenesis Nature Communications |
| author_facet |
Masahiro Yoshida Shunsuke Minagawa Jun Araya Taro Sakamoto Hiromichi Hara Kazuya Tsubouchi Yusuke Hosaka Akihiro Ichikawa Nayuta Saito Tsukasa Kadota Nahoko Sato Yusuke Kurita Kenji Kobayashi Saburo Ito Hirohumi Utsumi Hiroshi Wakui Takanori Numata Yumi Kaneko Shohei Mori Hisatoshi Asano Makoto Yamashita Makoto Odaka Toshiaki Morikawa Katsutoshi Nakayama Takeo Iwamoto Hirotaka Imai Kazuyoshi Kuwano |
| author_sort |
Masahiro Yoshida |
| title |
Involvement of cigarette smoke-induced epithelial cell ferroptosis in COPD pathogenesis |
| title_short |
Involvement of cigarette smoke-induced epithelial cell ferroptosis in COPD pathogenesis |
| title_full |
Involvement of cigarette smoke-induced epithelial cell ferroptosis in COPD pathogenesis |
| title_fullStr |
Involvement of cigarette smoke-induced epithelial cell ferroptosis in COPD pathogenesis |
| title_full_unstemmed |
Involvement of cigarette smoke-induced epithelial cell ferroptosis in COPD pathogenesis |
| title_sort |
involvement of cigarette smoke-induced epithelial cell ferroptosis in copd pathogenesis |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2019-07-01 |
| description |
Altered iron homeostasis resulting in excessive oxidative stress has been implicated in smoke-induced lung diseases. Here the authors show that ferroptosis of lung epithelial cells, potentially resulting from excessive ferritinophagy, is involved in the pathogenesis of COPD. |
| url |
https://doi.org/10.1038/s41467-019-10991-7 |
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1721445277109321728 |