Inhibition of spleen tyrosine kinase attenuates psoriasis-like inflammation in mice through blockade of dendritic cell-Th17 inflammation axis

Inhibition of spleen tyrosine kinase attenuates psoriasis-like inflammation in mice through blockade of dendritic cell-Th17 inflammation axis

Psoriasis is a debilitating autoimmune disease of the skin characterized by acanthosis and hyperkeratosis resulting from excessive growth of keratinocytes in the epidermis and inflammatory infiltrates in the dermis. Innate immune cells such as dendritic cells (DCs), perform a critical role in the pa...

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Bibliographic Details
Main Authors: Khalid S. Alzahrani, Ahmed Nadeem, Sheikh F. Ahmad, Naif O. Al-Harbi, Khalid E. Ibrahim, Ahmad M. El-Sherbeeny, Ali R. Alhoshani, Musaad A. Alshammari, Moureq R. Alotaibi, Mohammed M. Al-Harbi
Format: Article
Language:English
Published: Elsevier 2019-03-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Psoriasis
Spleen tyrosine kinase
Inflammation
Dendritic cell
Th17
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332218370665

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