Activation mechanism of ATP-sensitive K+ channels explored with real-time nucleotide binding

Activation mechanism of ATP-sensitive K+ channels explored with real-time nucleotide binding

The response of ATP-sensitive K+ channels (KATP) to cellular metabolism is coordinated by three classes of nucleotide binding site (NBS). We used a novel approach involving labeling of intact channels in a native, membrane environment with a non-canonical fluorescent amino acid and measurement (usin...

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Bibliographic Details
Main Authors: Michael Puljung, Natascia Vedovato, Samuel Usher, Frances Ashcroft
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-02-01
Series:eLife
Subjects:
allostery
binding
gating
diabetes
ligand
metabolism
Online Access:https://elifesciences.org/articles/41103

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