Acute Oxalate Nephropathy Associated with Orlistat: A Case Report with a Review of the Literature

Orlistat is a gastrointestinal lipase inhibitor used for weight reduction in obese individuals. Enteric hyperoxaluria caused by orlistat leads to oxalate absorption. Acute oxalate nephropathy is a rare complication of treatment with orlistat. Herein we report a patient presenting with acute renal fa...

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Main Authors: Dhara Chaudhari, Conchitina Crisostomo, Charles Ganote, George Youngberg
Format: Article
Language:English
Published: Hindawi Limited 2013-01-01
Series:Case Reports in Nephrology
Online Access:http://dx.doi.org/10.1155/2013/124604
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spelling doaj-7f913af2451d404e82a90b20f1c248e92020-11-24T21:11:13ZengHindawi LimitedCase Reports in Nephrology2090-66412090-665X2013-01-01201310.1155/2013/124604124604Acute Oxalate Nephropathy Associated with Orlistat: A Case Report with a Review of the LiteratureDhara Chaudhari0Conchitina Crisostomo1Charles Ganote2George Youngberg3Department of Internal Medicine, East Tennessee State University, Quillen College of Medicine, Johnson City, TN 37615, USADepartment of Nephrology, East Tennessee State University, Quillen College of Medicine, Johnson City, TN 37615, USADepartment of Pathology, East Tennessee State University, Quillen College of Medicine, Johnson City, TN 37615, USADepartment of Pathology, East Tennessee State University, Quillen College of Medicine, Johnson City, TN 37615, USAOrlistat is a gastrointestinal lipase inhibitor used for weight reduction in obese individuals. Enteric hyperoxaluria caused by orlistat leads to oxalate absorption. Acute oxalate nephropathy is a rare complication of treatment with orlistat. Herein we report a patient presenting with acute renal failure which improved minimal with intravenous hydration. She was found to have oxalate crystals on renal biopsy. Patient admitted orlistat use over the counter for weight reduction on further questioning. The purpose of this case review is to increase awareness among patients since they are more focused on losing weight. This case also calls for the provider attention to educate patients regarding side effects of orlistat because of easy availability of orlistat over the counter.http://dx.doi.org/10.1155/2013/124604
collection DOAJ
language English
format Article
sources DOAJ
author Dhara Chaudhari
Conchitina Crisostomo
Charles Ganote
George Youngberg
spellingShingle Dhara Chaudhari
Conchitina Crisostomo
Charles Ganote
George Youngberg
Acute Oxalate Nephropathy Associated with Orlistat: A Case Report with a Review of the Literature
Case Reports in Nephrology
author_facet Dhara Chaudhari
Conchitina Crisostomo
Charles Ganote
George Youngberg
author_sort Dhara Chaudhari
title Acute Oxalate Nephropathy Associated with Orlistat: A Case Report with a Review of the Literature
title_short Acute Oxalate Nephropathy Associated with Orlistat: A Case Report with a Review of the Literature
title_full Acute Oxalate Nephropathy Associated with Orlistat: A Case Report with a Review of the Literature
title_fullStr Acute Oxalate Nephropathy Associated with Orlistat: A Case Report with a Review of the Literature
title_full_unstemmed Acute Oxalate Nephropathy Associated with Orlistat: A Case Report with a Review of the Literature
title_sort acute oxalate nephropathy associated with orlistat: a case report with a review of the literature
publisher Hindawi Limited
series Case Reports in Nephrology
issn 2090-6641
2090-665X
publishDate 2013-01-01
description Orlistat is a gastrointestinal lipase inhibitor used for weight reduction in obese individuals. Enteric hyperoxaluria caused by orlistat leads to oxalate absorption. Acute oxalate nephropathy is a rare complication of treatment with orlistat. Herein we report a patient presenting with acute renal failure which improved minimal with intravenous hydration. She was found to have oxalate crystals on renal biopsy. Patient admitted orlistat use over the counter for weight reduction on further questioning. The purpose of this case review is to increase awareness among patients since they are more focused on losing weight. This case also calls for the provider attention to educate patients regarding side effects of orlistat because of easy availability of orlistat over the counter.
url http://dx.doi.org/10.1155/2013/124604
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AT conchitinacrisostomo acuteoxalatenephropathyassociatedwithorlistatacasereportwithareviewoftheliterature
AT charlesganote acuteoxalatenephropathyassociatedwithorlistatacasereportwithareviewoftheliterature
AT georgeyoungberg acuteoxalatenephropathyassociatedwithorlistatacasereportwithareviewoftheliterature
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