Quercetin reduce cardiomyocytes damage in type 2 diabetic rats

• Main Authors: Asri Hendrawati, Nadhir Nadhir
• Format: Article
• Language: English
• Published: Faculty of Medicine Trisakti University 2014-12-01
• Series: Universa Medicina
• Subjects: quercetin; glibenclamide; cardiomyocytes; type 2 diabetes mellitus; rats
• Online Access: https://univmed.org/ejurnal/index.php/medicina/article/view/20
• ISSN: 1907-3062; 2407-2230

BACKGROUND Diabetes mellitus (DM) is a group of metabolic diseases which are characterized by hyperglycemia, resulting in various complications. A major macrovascular complication of DM is cardiac failure due to cardiomyopathy. Hyperglycemia increases oxidative stress, so an oxidative-stress reducing therapeutic agent is required, e.g. the antioxidant quercetin. The aim of this study was to assess the effects of quercetin in reducing damage to cardiomyocytes of type 2 diabetic rats. METHODS This research is an experimental study using 40 rats. With simple random allocation, rats were divided into eight groups, then type 2 diabetes mellitus was induced using streptozotocin (5 rats per group). The test material was quercetin given at doses of 5, 20 and 80 mg/kgBW/day orally for 4 weeks. Each single dose of quercetin was given in combination with glibenclamide 5 mg/ kgBW/day. After 4 weeks the rats were decapitated and the cardiac tissues taken to quantify the percentage of cell damage after hematoxylin-eosin staining (HE). RESULTS Quercetin at a dose of 80 mg/kgBW/day can lower cardiomyocyte damage better than quercetin at doses of 5 or 20 mg/kgBW/day. A combination of quercetin and glibenclamide can significantly lower levels of cardiomyocyte damage better than quercetin without glibenclamide (p<0.05). CONCLUSION Quercetin at a dose of 80 mg/kgBW/day with or without glibenclamide can lower damage to cardiomyocytes of type 2 diabetic rats. Thus quercetin might serve as a valuable protective agent in cardiovascular inflammatory diseases in diabetic rats.