Primary peritoneal clear cell carcinoma. A case report and literature review

Primary peritoneal malignant tumors are exceptional. Among them, clear cell carcinoma is extremely rare, being only thirteen cases previously reported in the literature since 1990. We report a case of a 48-year-old Caucasian woman who was treated at the University General Hospital of Alicante. She c...

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Main Authors: Gloria Peiro, Sandra Silva-Ortega, Cristina Garcia-Espasa, Manuela Sala-Ferichola, Sandra Perez-Vicente, Elena Castellon-Molla, Josefa Marcos-Sanmartin
Format: Article
Language:English
Published: Elsevier 2020-05-01
Series:Gynecologic Oncology Reports
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Online Access:http://www.sciencedirect.com/science/article/pii/S2352578920300175
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spelling doaj-7f84d0f6dceb4c5b9c3d2bd141c6742c2020-11-25T02:11:12ZengElsevierGynecologic Oncology Reports2352-57892020-05-0132Primary peritoneal clear cell carcinoma. A case report and literature reviewGloria Peiro0Sandra Silva-Ortega1Cristina Garcia-Espasa2Manuela Sala-Ferichola3Sandra Perez-Vicente4Elena Castellon-Molla5Josefa Marcos-Sanmartin6Department of Pathology, Alicante University General Hospital, Alicante Institute for Health and Biomedical Research (ISABIAL-FISABIO Foundation), Alicante, SpainDepartment of Pathology, Alicante University General Hospital, Alicante Institute for Health and Biomedical Research (ISABIAL-FISABIO Foundation), Alicante, SpainDepartment of Radiology, Alicante University General Hospital, Alicante Institute for Health and Biomedical Research (ISABIAL-FISABIO Foundation), Alicante, SpainDepartment of Gynecology and Obstetrics, Alicante University General Hospital, Alicante Institute for Health and Biomedical Research (ISABIAL-FISABIO Foundation), Alicante, SpainDepartment of Gynecology and Obstetrics, Alicante University General Hospital, Alicante Institute for Health and Biomedical Research (ISABIAL-FISABIO Foundation), Alicante, SpainDepartment of Pathology, Alicante University General Hospital, Alicante Institute for Health and Biomedical Research (ISABIAL-FISABIO Foundation), Alicante, SpainDepartment of Gynecology and Obstetrics, Alicante University General Hospital, Alicante Institute for Health and Biomedical Research (ISABIAL-FISABIO Foundation), Alicante, Spain; Corresponding author at: Obstetrics and Gynecology Department, University General Hospital of Alicante, C/Pintor Baeza 12, 03010 Alicante, Spain.Primary peritoneal malignant tumors are exceptional. Among them, clear cell carcinoma is extremely rare, being only thirteen cases previously reported in the literature since 1990. We report a case of a 48-year-old Caucasian woman who was treated at the University General Hospital of Alicante. She consulted because of progressive abdominal pain over the last seven months, with the initial diagnosis of renal-ureteral colic. Ultrasound and computed tomography of the abdomen and pelvis revealed a 25 × 15 cm, well-defined cystic lesion with papillary projections, centrally located in the abdomen. The radiology report suggested a primary ovarian tumor versus peritoneal implant as the first option. The patient underwent an exploratory laparotomy showing a large cystic mass located in the urinary bladder peritoneum, firmly attached to the mesentery. The entire abdominal tumor was completely excised, and total hysterectomy with bilateral salpingo-oophorectomy and infra-colical omentectomy were performed. The final histological study revealed a new case of primary peritoneal clear cell carcinoma located in the urinary bladder peritoneum, firmly attached to the mesentery. Grossly, it was well-circumscribed and multicystic with papillary growth involving part of the inner wall. Microscopically, it showed tubulocystic and papillary patterns with highly atypical tumor cells. After an extensive immunohistochemical analysis, the most relevant finding was an ARID1A loss that was corroborated by molecular analysis showing an ARID1A deletion. The patient received systemic chemotherapy with carboplatin and paclitaxel protocol (Å ~ 4 cycles). Patient follow-up after the eighth month showed peritoneal implants predominantly in the right diaphragmatic cupule that were histologically confirmed as recurrence. She has just received another six cycles of chemotherapy with carboplatin and paclitaxel. Recognition of primary peritoneal clear cell carcinoma in this uncommon location, and exclude metastasis from the ovary, represents a diagnostic challenge.http://www.sciencedirect.com/science/article/pii/S2352578920300175Primary peritoneal clear cell carcinoma (PPCCC)NapsinAPD-L1PrognosisARID1A
collection DOAJ
language English
format Article
sources DOAJ
author Gloria Peiro
Sandra Silva-Ortega
Cristina Garcia-Espasa
Manuela Sala-Ferichola
Sandra Perez-Vicente
Elena Castellon-Molla
Josefa Marcos-Sanmartin
spellingShingle Gloria Peiro
Sandra Silva-Ortega
Cristina Garcia-Espasa
Manuela Sala-Ferichola
Sandra Perez-Vicente
Elena Castellon-Molla
Josefa Marcos-Sanmartin
Primary peritoneal clear cell carcinoma. A case report and literature review
Gynecologic Oncology Reports
Primary peritoneal clear cell carcinoma (PPCCC)
NapsinA
PD-L1
Prognosis
ARID1A
author_facet Gloria Peiro
Sandra Silva-Ortega
Cristina Garcia-Espasa
Manuela Sala-Ferichola
Sandra Perez-Vicente
Elena Castellon-Molla
Josefa Marcos-Sanmartin
author_sort Gloria Peiro
title Primary peritoneal clear cell carcinoma. A case report and literature review
title_short Primary peritoneal clear cell carcinoma. A case report and literature review
title_full Primary peritoneal clear cell carcinoma. A case report and literature review
title_fullStr Primary peritoneal clear cell carcinoma. A case report and literature review
title_full_unstemmed Primary peritoneal clear cell carcinoma. A case report and literature review
title_sort primary peritoneal clear cell carcinoma. a case report and literature review
publisher Elsevier
series Gynecologic Oncology Reports
issn 2352-5789
publishDate 2020-05-01
description Primary peritoneal malignant tumors are exceptional. Among them, clear cell carcinoma is extremely rare, being only thirteen cases previously reported in the literature since 1990. We report a case of a 48-year-old Caucasian woman who was treated at the University General Hospital of Alicante. She consulted because of progressive abdominal pain over the last seven months, with the initial diagnosis of renal-ureteral colic. Ultrasound and computed tomography of the abdomen and pelvis revealed a 25 × 15 cm, well-defined cystic lesion with papillary projections, centrally located in the abdomen. The radiology report suggested a primary ovarian tumor versus peritoneal implant as the first option. The patient underwent an exploratory laparotomy showing a large cystic mass located in the urinary bladder peritoneum, firmly attached to the mesentery. The entire abdominal tumor was completely excised, and total hysterectomy with bilateral salpingo-oophorectomy and infra-colical omentectomy were performed. The final histological study revealed a new case of primary peritoneal clear cell carcinoma located in the urinary bladder peritoneum, firmly attached to the mesentery. Grossly, it was well-circumscribed and multicystic with papillary growth involving part of the inner wall. Microscopically, it showed tubulocystic and papillary patterns with highly atypical tumor cells. After an extensive immunohistochemical analysis, the most relevant finding was an ARID1A loss that was corroborated by molecular analysis showing an ARID1A deletion. The patient received systemic chemotherapy with carboplatin and paclitaxel protocol (Å ~ 4 cycles). Patient follow-up after the eighth month showed peritoneal implants predominantly in the right diaphragmatic cupule that were histologically confirmed as recurrence. She has just received another six cycles of chemotherapy with carboplatin and paclitaxel. Recognition of primary peritoneal clear cell carcinoma in this uncommon location, and exclude metastasis from the ovary, represents a diagnostic challenge.
topic Primary peritoneal clear cell carcinoma (PPCCC)
NapsinA
PD-L1
Prognosis
ARID1A
url http://www.sciencedirect.com/science/article/pii/S2352578920300175
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